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    Pttg1 pituitary tumor-transforming gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 30939, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pttg1provided by MGI
    Official Full Name
    pituitary tumor-transforming gene 1provided by MGI
    Primary source
    MGI:MGI:1353578
    See related
    Ensembl:ENSMUSG00000020415 AllianceGenome:MGI:1353578
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pttg; Pttg3
    Summary
    Enables cysteine-type endopeptidase inhibitor activity. Acts upstream of or within homologous chromosome segregation; mitotic sister chromatid cohesion; and smoothened signaling pathway. Located in cytoplasm and nucleus. Is active in axoneme. Is expressed in several structures, including central nervous system; eye; limb; mesonephric tubule of male; and testis. Orthologous to several human genes including PTTG1 (PTTG1 regulator of sister chromatid separation, securin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 18.7), testis adult (RPKM 15.6) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pttg1 in Genome Data Viewer
    Location:
    11 B1.1; 11 25.68 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (43311097..43317417, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (43420244..43427463, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 146 Neighboring gene STARR-positive B cell enhancer ABC_E9138 Neighboring gene predicted gene 5782 Neighboring gene STARR-positive B cell enhancer ABC_E3940 Neighboring gene STARR-positive B cell enhancer ABC_E6968 Neighboring gene SLU7 splicing factor homolog (S. cerevisiae) Neighboring gene predicted gene 12151

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    securin
    Names
    pituitary tumor-transforming 1
    pituitary tumor-transforming gene 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131054.3NP_001124526.1  securin isoform 1

      See identical proteins and their annotated locations for NP_001124526.1

      Status: VALIDATED

      Source sequence(s)
      AL670472
      Consensus CDS
      CCDS48771.1
      UniProtKB/Swiss-Prot
      O88887, Q9CQJ7, Q9Z2E6
      UniProtKB/TrEMBL
      Q3Y5K4
      Related
      ENSMUSP00000020687.9, ENSMUST00000020687.15
      Conserved Domains (1) summary
      pfam04856
      Location:1188
      Securin; Securin sister-chromatid separation inhibitor
    2. NM_001362799.2NP_001349728.1  securin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670472
      Consensus CDS
      CCDS48771.1
      UniProtKB/Swiss-Prot
      O88887, Q9CQJ7, Q9Z2E6
      UniProtKB/TrEMBL
      Q3Y5K4
      Related
      ENSMUSP00000098894.5, ENSMUST00000101340.11
      Conserved Domains (1) summary
      pfam04856
      Location:1188
      Securin; Securin sister-chromatid separation inhibitor
    3. NM_001425538.1NP_001412467.1  securin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/Swiss-Prot
      O88887, Q9CQJ7, Q9Z2E6
      UniProtKB/TrEMBL
      Q3Y5K4
      Related
      ENSMUSP00000112834.2, ENSMUST00000118368.8
    4. NM_001425539.1NP_001412468.1  securin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/Swiss-Prot
      O88887, Q9CQJ7, Q9Z2E6
      UniProtKB/TrEMBL
      Q3Y5K4
      Related
      ENSMUSP00000112815.2, ENSMUST00000121638.8
    5. NM_001425540.1NP_001412469.1  securin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/Swiss-Prot
      O88887, Q9CQJ7, Q9Z2E6
      UniProtKB/TrEMBL
      Q3Y5K4
    6. NM_001425541.1NP_001412470.1  securin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/Swiss-Prot
      O88887, Q9CQJ7, Q9Z2E6
      UniProtKB/TrEMBL
      Q3Y5K4
    7. NM_001425542.1NP_001412471.1  securin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/TrEMBL
      Q3Y5K4
    8. NM_001425543.1NP_001412472.1  securin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/TrEMBL
      Q3Y5K4
    9. NM_001425544.1NP_001412473.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/TrEMBL
      Q3Y5K4
    10. NM_001425545.1NP_001412474.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/TrEMBL
      Q3Y5K4
    11. NM_001425546.1NP_001412475.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/TrEMBL
      Q3Y5K4
    12. NM_001425547.1NP_001412476.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/TrEMBL
      Q3Y5K4
      Related
      ENSMUSP00000020685.10, ENSMUST00000020685.10
    13. NM_001425548.1NP_001412477.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/TrEMBL
      Q3Y5K4
    14. NM_001425549.1NP_001412478.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/TrEMBL
      Q3Y5K4
    15. NM_001425550.1NP_001412479.1  securin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670472
      UniProtKB/TrEMBL
      Q3Y5K4
    16. NM_001425551.1NP_001412480.1  securin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL670472
    17. NM_001425552.1NP_001412481.1  securin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL670472
    18. NM_001425553.1NP_001412482.1  securin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL670472
    19. NM_013917.4NP_038945.2  securin isoform 2

      See identical proteins and their annotated locations for NP_038945.2

      Status: VALIDATED

      Source sequence(s)
      AL670472
      Consensus CDS
      CCDS24556.1
      UniProtKB/TrEMBL
      Q3Y5K4
      Related
      ENSMUSP00000112841.2, ENSMUST00000117446.8
      Conserved Domains (1) summary
      pfam04856
      Location:1173
      Securin; Securin sister-chromatid separation inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      43311097..43317417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)