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    Naip5 NLR family, apoptosis inhibitory protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 17951, updated on 3-Dec-2024

    Summary

    Official Symbol
    Naip5provided by MGI
    Official Full Name
    NLR family, apoptosis inhibitory protein 5provided by MGI
    Primary source
    MGI:MGI:1298220
    See related
    Ensembl:ENSMUSG00000071203 AllianceGenome:MGI:1298220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lgn1; Birc1e; Naip-rs3
    Summary
    Enables ATP binding activity. Involved in positive regulation of interleukin-1 beta production; pyroptotic inflammatory response; and response to bacterium. Acts upstream of or within symbiont entry into host cell. Part of IPAF inflammasome complex. Is expressed in several structures, including central nervous system; genitourinary system; heart; liver; and retina. Orthologous to human NAIP (NLR family apoptosis inhibitory protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 25.6), small intestine adult (RPKM 11.9) and 8 other tissues See more
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    Genomic context

    See Naip5 in Genome Data Viewer
    Location:
    13 D1; 13 53.05 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100348243..100387437, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100211735..100250930, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35471 Neighboring gene NLR family, apoptosis inhibitory protein 2 Neighboring gene myc induced nuclear antigen pseudogene Neighboring gene NLR family, apoptosis inhibitory protein 1, related sequence 1 Neighboring gene STARR-seq mESC enhancer starr_35472 Neighboring gene STARR-seq mESC enhancer starr_35473 Neighboring gene STARR-seq mESC enhancer starr_35474 Neighboring gene NLR family, apoptosis inhibitory protein 3, pseudogene 1 Neighboring gene NLR family, apoptosis inhibitory protein 6 Neighboring gene NLR family, apoptosis inhibitory protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (1) 
    • Spontaneous (1)  1 citation
    • Targeted (2)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detection of bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in detection of bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-1 beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pyroptotic inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pyroptotic inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_negative_effect regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within symbiont entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within symbiont entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of IPAF inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of IPAF inflammasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    baculoviral IAP repeat-containing protein 1e
    Names
    Legionella, susceptiblility 1
    baculoviral IAP repeat-containing 1e
    neuronal apoptosis inhibitory protein 5
    neuronal apoptosis inhibitory protein, related sequence 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426264.1NP_001413193.1  baculoviral IAP repeat-containing protein 1e isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT009518, CT030167
      UniProtKB/Swiss-Prot
      O09121, O09122, P81703, Q8CGT2, Q9R016, Q9R029
      UniProtKB/TrEMBL
      Q8CGT3
    2. NM_001426265.1NP_001413194.1  baculoviral IAP repeat-containing protein 1e isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT009518, CT030167
      UniProtKB/TrEMBL
      Q14B43
    3. NM_010870.3NP_035000.2  baculoviral IAP repeat-containing protein 1e isoform 1

      See identical proteins and their annotated locations for NP_035000.2

      Status: VALIDATED

      Source sequence(s)
      CT009518, CT030167
      Consensus CDS
      CCDS26727.1
      UniProtKB/Swiss-Prot
      O09121, O09122, P81703, Q8CGT2, Q9R016, Q9R029
      UniProtKB/TrEMBL
      Q8CGT3
      Conserved Domains (8) summary
      cd09293
      Location:10721271
      AMN1; Antagonist of mitotic exit network protein 1
      cd00022
      Location:279346
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      sd00033
      Location:10551078
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:11321156
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00653
      Location:162228
      BIR; Inhibitor of Apoptosis domain
      pfam05729
      Location:464618
      NACHT; NACHT domain
      pfam17779
      Location:688743
      NOD2_WH; NOD2 winged helix domain
      pfam17889
      Location:767873
      NLRC4_HD; NLRC4 helical domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      100348243..100387437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244631.3XP_011242933.1  baculoviral IAP repeat-containing protein 1e isoform X2

      UniProtKB/TrEMBL
      Q8CGT3
      Conserved Domains (8) summary
      cd09293
      Location:10261225
      AMN1; Antagonist of mitotic exit network protein 1
      cd00022
      Location:233300
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      sd00033
      Location:10091032
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:10861110
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00653
      Location:116182
      BIR; Inhibitor of Apoptosis domain
      pfam05729
      Location:418572
      NACHT; NACHT domain
      pfam17779
      Location:642697
      NOD2_WH; NOD2 winged helix domain
      pfam17889
      Location:721827
      NLRC4_HD; NLRC4 helical domain
    2. XM_017315416.2XP_017170905.1  baculoviral IAP repeat-containing protein 1e isoform X3

      UniProtKB/TrEMBL
      Q8CGT3
      Conserved Domains (6) summary
      cd00022
      Location:279346
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      sd00033
      Location:10551078
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00653
      Location:162228
      BIR; Inhibitor of Apoptosis domain
      pfam05729
      Location:464618
      NACHT; NACHT domain
      pfam17779
      Location:688743
      NOD2_WH; NOD2 winged helix domain
      pfam17889
      Location:767873
      NLRC4_HD; NLRC4 helical domain
    3. XM_017315417.2XP_017170906.1  baculoviral IAP repeat-containing protein 1e isoform X5

      UniProtKB/TrEMBL
      Q8CGT3
      Conserved Domains (7) summary
      cd09293
      Location:808927
      AMN1; Antagonist of mitotic exit network protein 1
      cd00022
      Location:1582
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      sd00034
      Location:868892
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:200354
      NACHT; NACHT domain
      pfam17779
      Location:424479
      NOD2_WH; NOD2 winged helix domain
      pfam17889
      Location:503609
      NLRC4_HD; NLRC4 helical domain
      cl39015
      Location:7991067
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    4. XM_017315415.3XP_017170904.1  baculoviral IAP repeat-containing protein 1e isoform X1

      UniProtKB/Swiss-Prot
      O09121, O09122, P81703, Q8CGT2, Q9R016, Q9R029
      UniProtKB/TrEMBL
      Q8CGT3
      Related
      ENSMUSP00000058611.3, ENSMUST00000049789.3
      Conserved Domains (8) summary
      cd09293
      Location:10721271
      AMN1; Antagonist of mitotic exit network protein 1
      cd00022
      Location:279346
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      sd00033
      Location:10551078
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:11321156
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00653
      Location:162228
      BIR; Inhibitor of Apoptosis domain
      pfam05729
      Location:464618
      NACHT; NACHT domain
      pfam17779
      Location:688743
      NOD2_WH; NOD2 winged helix domain
      pfam17889
      Location:767873
      NLRC4_HD; NLRC4 helical domain
    5. XM_036157899.1XP_036013792.1  baculoviral IAP repeat-containing protein 1e isoform X4

      UniProtKB/TrEMBL
      Q8CGT3
      Conserved Domains (7) summary
      cd09293
      Location:10721271
      AMN1; Antagonist of mitotic exit network protein 1
      cd00022
      Location:279346
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      sd00033
      Location:10551078
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00653
      Location:162228
      BIR; Inhibitor of Apoptosis domain
      pfam05729
      Location:464618
      NACHT; NACHT domain
      pfam17779
      Location:688743
      NOD2_WH; NOD2 winged helix domain
      pfam17889
      Location:767873
      NLRC4_HD; NLRC4 helical domain