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    Prdx3 peroxiredoxin 3 [ Mus musculus (house mouse) ]

    Gene ID: 11757, updated on 27-Nov-2024

    Summary

    Official Symbol
    Prdx3provided by MGI
    Official Full Name
    peroxiredoxin 3provided by MGI
    Primary source
    MGI:MGI:88034
    See related
    Ensembl:ENSMUSG00000024997 AllianceGenome:MGI:88034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aop1; Ef2l; Mer5; Prx3; SP22; TDXM; D0Tohi1
    Summary
    Enables identical protein binding activity. Acts upstream of or within several processes, including maternal placenta development; myeloid cell differentiation; and response to lipopolysaccharide. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; eye; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 32. Orthologous to human PRDX3 (peroxiredoxin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 248.6), heart adult (RPKM 175.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Prdx3 in Genome Data Viewer
    Location:
    19 D3; 19 56.52 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60852504..60862976, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60864066..60874538, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L26-like Neighboring gene DENN domain containing 10 Neighboring gene sideroflexin 4 Neighboring gene STARR-positive B cell enhancer ABC_E7678 Neighboring gene STARR-positive B cell enhancer ABC_E11681 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60965501-60965802 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60965940-60966241 Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene predicted gene 9529 Neighboring gene predicted gene, 22520

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables thioredoxin peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thioredoxin peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thioredoxin peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within maternal placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-cysteine oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    thioredoxin-dependent peroxide reductase, mitochondrial
    Names
    AOP-1
    Prx III
    anti-oxidant protein 1
    mitochondrial Trx dependent peroxide reductase
    mitochondrial thioredoxin dependent peroxide reductase
    perioredoxin-3
    peroxiredoxin III
    thioredoxin-dependent peroxiredoxin 3
    NP_031478.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007452.2NP_031478.1  thioredoxin-dependent peroxide reductase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_031478.1

      Status: VALIDATED

      Source sequence(s)
      AK002448, BB372344, BY318475
      Consensus CDS
      CCDS29944.1
      UniProtKB/Swiss-Prot
      P20108
      UniProtKB/TrEMBL
      Q8K4K8
      Related
      ENSMUSP00000025961.7, ENSMUST00000025961.7
      Conserved Domains (2) summary
      PTZ00253
      Location:70252
      PTZ00253; tryparedoxin peroxidase; Provisional
      cd03015
      Location:66236
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      60852504..60862976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)