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    Lrrn2 leucine rich repeat protein 2, neuronal [ Mus musculus (house mouse) ]

    Gene ID: 16980, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrn2provided by MGI
    Official Full Name
    leucine rich repeat protein 2, neuronalprovided by MGI
    Primary source
    MGI:MGI:106037
    See related
    Ensembl:ENSMUSG00000026443 AllianceGenome:MGI:106037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NLRR-2; 5730406J09Rik
    Summary
    Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including adrenal medulla; gut; nervous system; optic cup; and urinary system. Orthologous to human LRRN2 (leucine rich repeat neuronal 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 20.2), CNS E18 (RPKM 17.7) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrn2 in Genome Data Viewer
    Location:
    1 E4; 1 57.69 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132808093..132867743)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132880355..132940005)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31101 Neighboring gene predicted gene, 22609 Neighboring gene STARR-seq mESC enhancer starr_02263 Neighboring gene STARR-seq mESC enhancer starr_02264 Neighboring gene STARR-seq mESC enhancer starr_02265 Neighboring gene predicted gene, 31159 Neighboring gene predicted gene, 38687 Neighboring gene STARR-seq mESC enhancer starr_02266 Neighboring gene STARR-seq mESC enhancer starr_02269 Neighboring gene transformed mouse 3T3 cell double minute 4 Neighboring gene STARR-seq mESC enhancer starr_02270 Neighboring gene STARR-positive B cell enhancer ABC_E1560 Neighboring gene predicted gene 29257

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Taguchi A, et al. Brain Res Mol Brain Res, 1996 Jan. PMID 8717337
    2. The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts. Haines BP, et al. Dev Biol, 2005 May 15. PMID 15893969
    3. Expression profile of protein kinase C isozymes in preimplantation mouse development. Dehghani H, et al. Reproduction, 2005 Oct. PMID 16183862
    4. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Homma S, et al. Gene Expr Patterns, 2009 Jan. PMID 18848646
    5. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Yoshida Y, et al. Neuron, 2006 Dec 7. PMID 17145500, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NLRR-2 expression appears to be predominately confined to the adult.
      Title: The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat neuronal protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010732.4 → NP_034862.1  leucine-rich repeat neuronal protein 2 precursor

      See identical proteins and their annotated locations for NP_034862.1

      Status: VALIDATED

      Source sequence(s)
      AK039216, BB342744, BC056458
      Consensus CDS
      CCDS15289.1
      UniProtKB/TrEMBL
      Q6PHP6, Q6US92
      Related
      ENSMUSP00000027706.4, ENSMUST00000027706.4
      Conserved Domains (7) summary
      cd00116
      Location:62 → 288
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:430 → 514
      I-set; Immunoglobulin I-set domain
      sd00031
      Location:337 → 360
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:95 → 118
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:117 → 177
      LRR_8; Leucine rich repeat
      cl11960
      Location:438 → 514
      Ig; Immunoglobulin domain
      cl15307
      Location:369 → 412
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      132808093..132867743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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