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    GDH3 glutamate dehydrogenase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821072, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GDH3
    Official Full Name
    glutamate dehydrogenase 3
    Primary source
    TAIR:AT3G03910
    Locus tag
    AT3G03910
    See related
    Araport:AT3G03910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F20H23.4; glutamate dehydrogenase 3
    Summary
    GDH3 encodes a member of the glutamate dehydrogenease family. Its expression is upregulated in response to cytokinin and it may play a role in the control of nitrogen metabolism in leaf development.
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    Genomic context

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    See GDH3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (1006780..1009018)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene sterol O-acyltransferase, putative (DUF1639) Neighboring gene FMN binding protein Neighboring gene adenosine-5'-phosphosulfate (APS) kinase 3 Neighboring gene ncRNA Neighboring gene H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 protein Neighboring gene ncRNA Neighboring gene kinase-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glutamate dehydrogenase isoenzyme 3 (GDH3) of Arabidopsis thaliana is less thermostable than GDH1 and GDH2 isoenzymes. Marchi L, et al. Plant Physiol Biochem, 2014 Oct. PMID 25180813
    2. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    3. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the carboxyl terminus of the GDH subunit is involved in the stabilization of the oligomeric structure of the enzyme.
      Title: Glutamate dehydrogenase isoenzyme 3 (GDH3) of Arabidopsis thaliana is less thermostable than GDH1 and GDH2 isoenzymes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001337494.1
    NM_111262.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    glutamate dehydrogenase 3
    NP_187041.1
    • glutamate dehydrogenase 3 (GDH3); FUNCTIONS IN: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor, oxidoreductase activity, binding, catalytic activity; INVOLVED IN: regulation of nitrogen compound metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Glutamate/phenylalanine/leucine/valine dehydrogenase (InterPro:IPR006095), Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal (InterPro:IPR006096), Glutamate dehydrogenase (InterPro:IPR014362), NAD(P)-binding domain (InterPro:IPR016040), Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain (InterPro:IPR006097); BEST Arabidopsis thaliana protein match is: glutamate dehydrogenase 1 (TAIR:AT5G18170.1); Has 8937 Blast hits to 8931 proteins in 2306 species: Archae - 305; Bacteria - 5351; Metazoa - 356; Fungi - 208; Plants - 399; Viruses - 0; Other Eukaryotes - 2318 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1006780..1009018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111262.2 → NP_187041.1  glutamate dehydrogenase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187041.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9S7A0
      UniProtKB/TrEMBL
      A0A178VBI2, A0A5S9X8V6, A0A654F3W8
      Conserved Domains (1) summary
      PLN02477
      Location:1 → 410
      PLN02477; glutamate dehydrogenase

    2. NM_001337494.1 → NP_001326159.1  glutamate dehydrogenase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LNF1, A0A654F3W8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S7A0.1

    Gene LinkOut

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