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    ABCB19 ATP binding cassette subfamily B19 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822519, updated on 17-Oct-2024

    Summary

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    Official Symbol
    ABCB19
    Official Full Name
    ATP binding cassette subfamily B19
    Primary source
    TAIR:AT3G28860
    Locus tag
    AT3G28860
    See related
    Araport:AT3G28860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana ATP-binding cassette B19; ATABCB19; ATMDR1; ATMDR11; ATP binding cassette subfamily B19; ATP BINDING CASSETTE SUBFAMILY B19; ATP-binding cassette B19; ATPGP19; MDR1; MDR11; MULTIDRUG RESISTANCE PROTEIN 11; P-GLYCOPROTEIN 19; PGP19
    Summary
    Encodes a member of the ATP-binding cassette (ABC) transporter family that is involved in auxin transport and is involved in postembryonic organ separation. Also known as AtMDR11 and PGP19. Possibly regulates auxin-dependent responses by influencing basipetal auxin transport in the root. Acts upstream of phyA in regulating hypocotyl elongation and gravitropic response. Exerts nonredundantly overlapping functions with the ABC transporter encoded by AtPGP1.
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    Genomic context

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    See ABCB19 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (10870005..10877578, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene basic helix-loop-helix (bHLH) DNA-binding family protein Neighboring gene pseudo Neighboring gene paired amphipathic helix SIN3-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Ying W, et al. Science, 2024 Mar 22. PMID 38513023
    2. Multidrug resistance-like genes of Arabidopsis required for auxin transport and auxin-mediated development. Noh B, et al. Plant Cell, 2001 Nov. PMID 11701880, Free PMC Article
    3. Mutations in Arabidopsis multidrug resistance-like ABC transporters separate the roles of acropetal and basipetal auxin transport in lateral root development. Wu G, et al. Plant Cell, 2007 Jun. PMID 17557807, Free PMC Article
    4. The ABC subfamily B auxin transporter AtABCB19 is involved in the inhibitory effects of N-1-naphthyphthalamic acid on the phototropic and gravitropic responses of Arabidopsis hypocotyls. Nagashima A, et al. Plant Cell Physiol, 2008 Aug. PMID 18556728
    5. Auxin transport into cotyledons and cotyledon growth depend similarly on the ABCB19 Multidrug Resistance-like transporter. Lewis DR, et al. Plant J, 2009 Oct. PMID 19508431

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ABCB19 transporter: fostering brassinosteroid transport through membrane flexibility.
      Title: ABCB19 transporter: fostering brassinosteroid transport through membrane flexibility.
    2. Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
      Title: Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
    3. ABCB19 is associated with cytoplasmic streaming and gravitropism in Arabidopsis.
      Title: An ABC transporter B family protein, ABCB19, is required for cytoplasmic streaming and gravitropism of the inflorescence stems.
    4. Data show ABCB19-mediated polar auxin transport modulates Arabidopsis hypocotyl elongation and the endoreplication variant of the cell cycle.
      Title: ABCB19-mediated polar auxin transport modulates Arabidopsis hypocotyl elongation and the endoreplication variant of the cell cycle.
    5. ABCB1 plays a major role during anther development, while ABCB19 has a synergistic role.
      Title: ABCB1 and ABCB19 auxin transporters have synergistic effects on early and late Arabidopsis anther development.
    6. Ion channel activity of ABCB19 that is blocked by NPPB, a compound that can now be considered an inhibitor of polar auxin transport with a defined molecular target.
      Title: Block of ATP-binding cassette B19 ion channel activity by 5-nitro-2-(3-phenylpropylamino)-benzoic acid impairs polar auxin transport and root gravitropism.
    7. ABCB19 takes part in adventitious root formation in Arabidopsis.
      Title: Localized induction of the ATP-binding cassette B19 auxin transporter enhances adventitious root formation in Arabidopsis.
    8. The ATP-binding cassette transporter ABCB19 regulates postembryonic organ separation in Arabidopsis.
      Title: The ATP-binding cassette transporter ABCB19 regulates postembryonic organ separation in Arabidopsis.
    9. Structural sterols and sphingolipids regulate ABCB19-GFP trafficking between the trans-Golgi network and the plasma membrane.
      Title: Sterols and sphingolipids differentially function in trafficking of the Arabidopsis ABCB19 auxin transporter.
    10. Phosphorylation of ABCB19 by phot1 inhibits its efflux activity, thereby increasing auxin levels in and above the hypocotyl apex.
      Title: phot1 inhibition of ABCB19 primes lateral auxin fluxes in the shoot apex required for phototropism.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_113807.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables auxin efflux transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acropetal auxin transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within anthocyanin accumulation in tissues in response to UV light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within auxin transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within basipetal auxin transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within formation of plant organ boundary IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lateral root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive gravitropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to blue light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to far red light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red or far red light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stamen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP binding cassette subfamily B19
    NP_189528.1
    • ATP binding cassette subfamily B19 (ABCB19); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, auxin efflux transmembrane transporter activity; INVOLVED IN: in 14 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ATP binding cassette subfamily B1 (TAIR:AT2G36910.1); Has 832220 Blast hits to 388750 proteins in 4155 species: Archae - 14331; Bacteria - 653917; Metazoa - 17455; Fungi - 11958; Plants - 9253; Viruses - 33; Other Eukaryotes - 125273 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      10870005..10877578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113807.3 → NP_189528.1  ATP binding cassette subfamily B19 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189528.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GZ77, Q8H6F5, Q9LJX0
      UniProtKB/TrEMBL
      A0A5S9XGL2, A0A654FCP4
      Conserved Domains (1) summary
      PTZ00265
      Location:17 → 1247
      PTZ00265; multidrug resistance protein (mdr1); Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LJX0.1

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