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    MKP2 MAPK phosphatase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819784, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MKP2
    Official Full Name
    MAPK phosphatase 2
    Primary source
    TAIR:AT3G06110
    Locus tag
    AT3G06110
    See related
    Araport:AT3G06110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS MAPK PHOSPHATASE 2; ATMKP2; DSPTP1B; DUAL-SPECIFICITY PROTEIN PHOSPHATASE 1B; F28L1.5; F28L1_5; MAPK phosphatase 2
    Summary
    Encodes a nuclear-localized MAP kinase phosphatase. Plants with reduced levels of MKP2 transcripts are hypersensitive to ozone and ozone-mediated activation of MPK3 and MPK6 is prolonged in these plants.
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    Genomic context

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    See MKP2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (1843413..1845062)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene NOD26-like intrinsic protein 7;1 Neighboring gene tRNA-Gly Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of MAPK signaling and cell death by MAPK phosphatase MKP2. Vilela B, et al. Plant Signal Behav, 2010 Nov. PMID 21057191, Free PMC Article
    2. Gene network analysis and functional studies of senescence-associated genes reveal novel regulators of Arabidopsis leaf senescence. Li Z, et al. J Integr Plant Biol, 2012 Aug. PMID 22709441
    3. MAPK phosphatase MKP2 mediates disease responses in Arabidopsis and functionally interacts with MPK3 and MPK6. Lumbreras V, et al. Plant J, 2010 Sep. PMID 20626661
    4. Arabidopsis MAPK phosphatase 2 (MKP2) positively regulates oxidative stress tolerance and inactivates the MPK3 and MPK6 MAPKs. Lee JS, et al. J Biol Chem, 2007 Aug 24. PMID 17586809
    5. Regulation of the dual specificity protein phosphatase, DsPTP1, through interactions with calmodulin. Yoo JH, et al. J Biol Chem, 2004 Jan 9. PMID 14570888

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. silencing promoted early leaf senescence
      Title: Gene network analysis and functional studies of senescence-associated genes reveal novel regulators of Arabidopsis leaf senescence.
    2. This study describes the interplay of MAPK and MKP2 phosphatase signaling during cell death responses elicited by host-pathogen interactions.[MKP2]
      Title: Regulation of MAPK signaling and cell death by MAPK phosphatase MKP2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001202892.1
    NM_111486.3
    NM_180191.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in negative regulation of plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ozone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    MAPK phosphatase 2
    NP_001189821.1
    • MAPK phosphatase 2 (MKP2); CONTAINS InterPro DOMAIN/s: Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: dual specificity protein phosphatase 1 (TAIR:AT3G23610.2).
    NP_566272.1
    • MAPK phosphatase 2 (MKP2); FUNCTIONS IN: MAP kinase phosphatase activity, protein tyrosine/serine/threonine phosphatase activity; INVOLVED IN: intracellular protein kinase cascade, response to ozone, negative regulation of MAP kinase activity, response to stress; LOCATED IN: nucleus, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: dual specificity protein phosphatase 1 (TAIR:AT3G23610.2); Has 4028 Blast hits to 4023 proteins in 348 species: Archae - 21; Bacteria - 87; Metazoa - 2101; Fungi - 442; Plants - 308; Viruses - 204; Other Eukaryotes - 865 (source: NCBI BLink).
    NP_850522.1
    • MAPK phosphatase 2 (MKP2); FUNCTIONS IN: MAP kinase phosphatase activity, protein tyrosine/serine/threonine phosphatase activity; INVOLVED IN: intracellular protein kinase cascade, response to ozone, negative regulation of MAP kinase activity, response to stress; LOCATED IN: nucleus, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: dual specificity protein phosphatase 1 (TAIR:AT3G23610.2); Has 4168 Blast hits to 4160 proteins in 377 species: Archae - 19; Bacteria - 125; Metazoa - 2129; Fungi - 477; Plants - 302; Viruses - 229; Other Eukaryotes - 887 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1843413..1845062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202892.1 → NP_001189821.1  MAPK phosphatase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189821.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LDW2, Q9M8K7
      UniProtKB/TrEMBL
      A0A5S9X9K9, A0A654F4I8
      Conserved Domains (1) summary
      cd14498
      Location:26 → 158
      DSP; dual-specificity phosphatase domain

    2. NM_180191.3 → NP_850522.1  MAPK phosphatase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850522.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LDW2, Q9M8K7
      UniProtKB/TrEMBL
      A0A5S9X9K9, A0A654F4I8
      Conserved Domains (1) summary
      cd14498
      Location:26 → 158
      DSP; dual-specificity phosphatase domain

    3. NM_111486.3 → NP_566272.1  MAPK phosphatase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566272.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M8K7
      Conserved Domains (1) summary
      cd00127
      Location:25 → 150
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M8K7.1

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