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    ALN allantoinase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825836, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALN
    Official Full Name
    allantoinase
    Primary source
    TAIR:AT4G04955
    Locus tag
    AT4G04955
    See related
    Araport:AT4G04955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    allantoinase; ATALN
    Summary
    Encodes an allantoinase which is involved in allantoin degradation and assimilation. Gene expression was induced when allantoin was added to the medium. The insertion mutant, ataln m2-1, did not grow well on the MS medium where allantoin, instead of ammonium nitrate, was supplied.
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    Genomic context

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    See ALN in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    15
    Sequence:
    Chromosome: 4; NC_003075.7 (2522034..2525352, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene fatty acid desaturase family protein Neighboring gene transducin family protein / WD-40 repeat family protein Neighboring gene thioredoxin family protein Neighboring gene RRM in demeter (DUF1985) Neighboring gene Concanavalin A-like lectin protein kinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of allantoinase genes from Arabidopsis and a nonureide-type legume black locust. Yang J, et al. Plant Physiol, 2004 Mar. PMID 14976234, Free PMC Article
    2. Allantoin accumulation mediated by allantoinase downregulation and transport by Ureide Permease 5 confers salt stress tolerance to Arabidopsis plants. Lescano CI, et al. Plant Mol Biol, 2016 Jul. PMID 27209043
    3. Identification, biochemical characterization, and subcellular localization of allantoate amidohydrolases from Arabidopsis and soybean. Werner AK, et al. Plant Physiol, 2008 Feb. PMID 18065556, Free PMC Article
    4. The ureide-degrading reactions of purine ring catabolism employ three amidohydrolases and one aminohydrolase in Arabidopsis, soybean, and rice. Werner AK, et al. Plant Physiol, 2013 Oct. PMID 23940254, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ups5 knockout plants under salt stress presented a susceptible phenotype and altered allantoin root-to-shoot content ratios.
      Title: Allantoin accumulation mediated by allantoinase downregulation and transport by Ureide Permease 5 confers salt stress tolerance to Arabidopsis plants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001340521.1
    NM_116734.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables allantoinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables allantoinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables allantoinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables allantoinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cobalt ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in allantoin catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to nitrogen starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within purine nucleobase catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ureide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    allantoinase
    NP_567276.1
    • allantoinase (ALN); CONTAINS InterPro DOMAIN/s: Amidohydrolase 1 (InterPro:IPR006680), Allantoinase (InterPro:IPR017593), Metal-dependent hydrolase, composite domain (InterPro:IPR011059); BEST Arabidopsis thaliana protein match is: pyrimidine 2 (TAIR:AT5G12200.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      2522034..2525352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116734.3 → NP_567276.1  allantoinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567276.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LCA4, Q94AP0
      UniProtKB/TrEMBL
      A0A5S9XQN0, A0A654FLV2
      Conserved Domains (2) summary
      PLN02795
      Location:1 → 505
      PLN02795; allantoinase
      cd01315
      Location:44 → 503
      L-HYD_ALN; L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in ...

    2. NM_001340521.1 → NP_001328262.1  allantoinase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B436, A0A5S9XQN0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AP0.1

    Gene LinkOut

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