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    GGT1 gamma-glutamyl transpeptidase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830118, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GGT1
    Official Full Name
    gamma-glutamyl transpeptidase 1
    Primary source
    TAIR:AT4G39640
    Locus tag
    AT4G39640
    See related
    Araport:AT4G39640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    gamma-glutamyl transpeptidase 1; T19P19.30; T19P19_30
    Summary
    The gene encodes a gamma-glutamyltransferase (AKA gamma-glutamyl transpeptidase, EC 2.3.2.2) that is located in vascular tissues (predominantly phloem) of leaves and is involved in the degradation of glutathione. The encoded enzyme also mitigates oxidative stress by metabolizing GSSG (oxidized form of GSH - glutathione) in the apoplast.
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    Genomic context

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    See GGT1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (18399923..18403067)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene translation initiation factor Neighboring gene gamma-glutamyl transpeptidase 2 Neighboring gene alanine:glyoxylate aminotransferase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical and quantitative proteomics investigations in Arabidopsis ggt1 mutant leaves reveal a role for the gamma-glutamyl cycle in plant's adaptation to environment. Tolin S, et al. Proteomics, 2013 Jun. PMID 23661340
    2. Characterization of the extracellular gamma-glutamyl transpeptidases, GGT1 and GGT2, in Arabidopsis. Ohkama-Ohtsu N, et al. Plant J, 2007 Mar. PMID 17316175
    3. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using proteomic analyses in the Arabidopsis thaliana ggt1 knockout mutant to study role of ggt1 in Arabidopsis thaliana proteome.
      Title: Biochemical and quantitative proteomics investigations in Arabidopsis ggt1 mutant leaves reveal a role for the gamma-glutamyl cycle in plant's adaptation to environment.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_120124.6
    NM_202988.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glutathione gamma-glutamylcysteinyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene C4 gamma-glutamyl transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glutathione catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    gamma-glutamyl transpeptidase 1
    NP_195674.2
    • gamma-glutamyl transpeptidase 1 (GGT1); FUNCTIONS IN: gamma-glutamyltransferase activity, glutathione gamma-glutamylcysteinyltransferase activity; INVOLVED IN: response to oxidative stress, glutathione catabolic process; LOCATED IN: apoplast, plant-type cell wall; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Gamma-glutamyltranspeptidase (InterPro:IPR000101); BEST Arabidopsis thaliana protein match is: gamma-glutamyl transpeptidase 2 (TAIR:AT4G39650.1); Has 9168 Blast hits to 9144 proteins in 1483 species: Archae - 86; Bacteria - 4247; Metazoa - 703; Fungi - 305; Plants - 110; Viruses - 1; Other Eukaryotes - 3716 (source: NCBI BLink).
    NP_974717.1
    • gamma-glutamyl transpeptidase 1 (GGT1); FUNCTIONS IN: gamma-glutamyltransferase activity, glutathione gamma-glutamylcysteinyltransferase activity; INVOLVED IN: response to oxidative stress, glutathione catabolic process; LOCATED IN: apoplast, plant-type cell wall; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Gamma-glutamyltranspeptidase (InterPro:IPR000101); BEST Arabidopsis thaliana protein match is: gamma-glutamyl transpeptidase 2 (TAIR:AT4G39650.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      18399923..18403067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120124.6 → NP_195674.2  gamma-glutamyl transpeptidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195674.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DI67, O65652, Q8VYW6
      UniProtKB/TrEMBL
      A0A178UXW6, A0A5S9Y0D7
      Conserved Domains (1) summary
      PLN02198
      Location:1 → 572
      PLN02198; glutathione gamma-glutamylcysteinyltransferase

    2. NM_202988.4 → NP_974717.1  gamma-glutamyl transpeptidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974717.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DI67, O65652, Q8VYW6
      UniProtKB/TrEMBL
      A0A178UXW6, A0A5S9Y0D7
      Conserved Domains (1) summary
      PLN02198
      Location:1 → 572
      PLN02198; glutathione gamma-glutamylcysteinyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VYW6.1

    Gene LinkOut

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