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    RPP1 Disease resistance protein (TIR-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823573, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPP1
    Official Full Name
    Disease resistance protein (TIR-NBS-LRR class) family
    Primary source
    TAIR:AT3G44480
    Locus tag
    AT3G44480
    See related
    Araport:AT3G44480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cog1; recognition of peronospora parasitica 1
    Summary
    Encodes a TIR-NB-LRR R-protein RPP1 that confers resistance to Peronospora parasitica (downy mildew).
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    Genomic context

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    See RPP1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (16090460..16096477, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene pseudo Neighboring gene Low molecular weight phosphotyrosine protein phosphatase Neighboring gene histone deacetylase 17 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Ma S, et al. Science, 2020 Dec 4. PMID 33273071
    2. Multiple Domain Associations within the Arabidopsis Immune Receptor RPP1 Regulate the Activation of Programmed Cell Death. Schreiber KJ, et al. PLoS Pathog, 2016 Jul. PMID 27427964, Free PMC Article
    3. Recognition and activation domains contribute to allele-specific responses of an Arabidopsis NLR receptor to an oomycete effector protein. Steinbrenner AD, et al. PLoS Pathog, 2015 Feb. PMID 25671309, Free PMC Article
    4. The Arabidopsis thaliana TIR-NB-LRR R-protein, RPP1A; protein localization and constitutive activation of defence by truncated alleles in tobacco and Arabidopsis. Michael Weaver L, et al. Plant J, 2006 Sep. PMID 16889647
    5. Differential recognition of highly divergent downy mildew avirulence gene alleles by RPP1 resistance genes from two Arabidopsis lines. Rehmany AP, et al. Plant Cell, 2005 Jun. PMID 15894715, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Dof transcription factor COG1 acts as a key regulator of plant biomass by promoting photosynthesis and starch accumulation.
      Title: The Dof transcription factor COG1 acts as a key regulator of plant biomass by promoting photosynthesis and starch accumulation.
    2. Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme.
      Title: Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme.
    3. PRX2 and PRX25, peroxidases regulated by COG1, are involved in seed longevity in Arabidopsis.
      Title: PRX2 and PRX25, peroxidases regulated by COG1, are involved in seed longevity in Arabidopsis.
    4. COG1 binds to the promoter regions of PIF4 and PIF5, and PIF4 and PIF5 bind to the promoter regions of key Brassinosteroid biosynthetic genes, such as DWF4 and BR6ox2, to directly promote their expression.
      Title: Brassinosteroid Biosynthesis Is Modulated via a Transcription Factor Cascade of COG1, PIF4, and PIF5.
    5. In this study, we sought to functionally characterize the domains of RPP1 with regards to cell death induction following effector recognition
      Title: Multiple Domain Associations within the Arabidopsis Immune Receptor RPP1 Regulate the Activation of Programmed Cell Death.
    6. inclusion of the RPP1-NdA ARC2 subdomain, from the central NB-ARC domain, was required for a full range of activation specificity.
      Title: Recognition and activation domains contribute to allele-specific responses of an Arabidopsis NLR receptor to an oomycete effector protein.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001339142.1
    NM_001339143.1
    NM_001339144.1
    NM_114316.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables LRR domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oomycetes IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Disease resistance protein (TIR-NBS-LRR class) family
    NP_190034.2
    • recognition of peronospora parasitica 1 (RPP1); CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT3G44630.1); Has 46378 Blast hits to 25771 proteins in 899 species: Archae - 34; Bacteria - 2351; Metazoa - 4746; Fungi - 347; Plants - 36039; Viruses - 14; Other Eukaryotes - 2847 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      16090460..16096477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339141.1 → NP_001326422.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LP83, A0A5S9XIL8

    2. NM_114316.3 → NP_190034.2  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190034.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4J339, Q9LXN9
      UniProtKB/TrEMBL
      A0A5S9XIL8
      Conserved Domains (6) summary
      cd00009
      Location:298 → 415
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      cd09293
      Location:697 → 917
      AMN1; Antagonist of mitotic exit network protein 1
      PLN03210
      Location:89 → 1176
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00033
      Location:693 → 715
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:98 → 263
      TIR; TIR domain
      pfam07725
      Location:692 → 711
      LRR_3; Leucine Rich Repeat

    3. NM_001339143.1 → NP_001326419.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4J339, Q9LXN9
      UniProtKB/TrEMBL
      A0A5S9XIL8

    4. NM_001339142.1 → NP_001326421.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LP82, A0A5S9XIL8

    5. NM_001339144.1 → NP_001326420.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LP82, A0A5S9XIL8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4J339.1

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