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    ABCG14 ATP-binding cassette 14 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840064, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABCG14
    Official Full Name
    ATP-binding cassette 14
    Primary source
    TAIR:AT1G31770
    Locus tag
    AT1G31770
    See related
    Araport:AT1G31770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtABCG14; ATP-binding cassette 14; ATP-binding cassette G14; F5M6.22
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    Genomic context

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    See ABCG14 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (11374760..11377885, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene proline-rich family protein Neighboring gene SWIB/MDM2 domain superfamily protein Neighboring gene miscRNA Neighboring gene Defensin-like (DEFL) family protein Neighboring gene oligomeric golgi complex subunit Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene cytochrome P450, family 97, subfamily A, polypeptide 3 Neighboring gene Formin Homology 14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis ABCG14 forms a homodimeric transporter for multiple cytokinins and mediates long-distance transport of isopentenyladenine-type cytokinins. Zhao J, et al. Plant Commun, 2023 Mar 13. PMID 36307987, Free PMC Article
    2. A Role of Cytokinin Transporter in Arabidopsis Immunity. Wang S, et al. Mol Plant Microbe Interact, 2017 Apr. PMID 28398838
    3. Arabidopsis ABCG14 is essential for the root-to-shoot translocation of cytokinin. Ko D, et al. Proc Natl Acad Sci U S A, 2014 May 13. PMID 24778257, Free PMC Article
    4. Arabidopsis ABCG14 protein controls the acropetal translocation of root-synthesized cytokinins. Zhang K, et al. Nat Commun, 2014. PMID 24513716
    5. Cytokinin Response Factor 6 Represses Cytokinin-Associated Genes during Oxidative Stress. Zwack PJ, et al. Plant Physiol, 2016 Oct. PMID 27550996, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis ABCG14 forms a homodimeric transporter for multiple cytokinins and mediates long-distance transport of isopentenyladenine-type cytokinins.
      Title: Arabidopsis ABCG14 forms a homodimeric transporter for multiple cytokinins and mediates long-distance transport of isopentenyladenine-type cytokinins.
    2. ABCG14 transports Cytokinin (CK) from roots to the shoots, and the suppression of the SNC1-mediated defense response by the loss of ABCG14 is due to a deficiency of trans-zeatin (tZ)-type CK in the shoot.
      Title: A Role of Cytokinin Transporter in Arabidopsis Immunity.
    3. ABCG14, is essential for the acropetal translocation of the root-synthesized cytokinins. Knocking out AtABCG14 strongly impairs the translocation of cytokinins from roots to shoots, thereby affecting the plant's growth and development.
      Title: Arabidopsis ABCG14 protein controls the acropetal translocation of root-synthesized cytokinins.
    4. results indicate that AtABCG14 is crucial for the translocation of cytokinin to the shoot.
      Title: Arabidopsis ABCG14 is essential for the root-to-shoot translocation of cytokinin.
    5. ABCG9, ABCG11 and ABCG14 are expressed in the vascular system. Mutations are responsible for defects in plant growth and affect vascular patterning.
      Title: ABCG9, ABCG11 and ABCG14 ABC transporters are required for vascular development in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_102911.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ABC-type transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cytokinin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cotyledon vascular tissue pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cotyledon vascular tissue pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytokinin transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytokinin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in export from cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stem vascular tissue pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette 14
    NP_564383.1
    • ATP-binding cassette 14 (ABCG14); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances; LOCATED IN: membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC-2 type transporter (InterPro:IPR013525), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ABC-2 type transporter family protein (TAIR:AT3G25620.2); Has 394116 Blast hits to 359785 proteins in 4146 species: Archae - 7090; Bacteria - 311308; Metazoa - 8766; Fungi - 6614; Plants - 5656; Viruses - 7; Other Eukaryotes - 54675 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11374760..11377885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102911.3 → NP_564383.1  ATP-binding cassette 14 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C6R7, Q9C6W5
      UniProtKB/TrEMBL
      A0A178WG70, A0A5S9WK34
      Conserved Domains (1) summary
      PLN03211
      Location:10 → 646
      PLN03211; ABC transporter G-25; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C6W5.1

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