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    XLG3 extra-large GTP-binding protein 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840083, updated on 18-Sep-2024

    Summary

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    Official Symbol
    XLG3
    Official Full Name
    extra-large GTP-binding protein 3
    Primary source
    TAIR:AT1G31930
    Locus tag
    AT1G31930
    See related
    Araport:AT1G31930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    extra-large GTP-binding protein 3; F5M6.7; F5M6_7
    Summary
    Encodes XLG3 (extra-large G protein 3) that shows significant similarity to the G protein alpha subunit in its C terminal region. Involved in the regulation of root morphological and growth responses.
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    Genomic context

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    See XLG3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (11464934..11469207)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene GHMP kinase family protein Neighboring gene miscRNA Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA Neighboring gene cystic fibrosis transmembrane conductance regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis extra large G-protein 2 (XLG2) interacts with the Gbeta subunit of heterotrimeric G protein and functions in disease resistance. Zhu H, et al. Mol Plant, 2009 May. PMID 19825634, Free PMC Article
    2. Regulation of root-wave response by extra large and conventional G proteins in Arabidopsis thaliana. Pandey S, et al. Plant J, 2008 Jul. PMID 18397373
    3. Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity. Wang Y, et al. J Integr Plant Biol, 2023 Mar. PMID 36250681
    4. Extra-Large G Proteins Expand the Repertoire of Subunits in Arabidopsis Heterotrimeric G Protein Signaling. Chakravorty D, et al. Plant Physiol, 2015 Sep. PMID 26157115, Free PMC Article
    5. Arabidopsis extra-large G proteins (XLGs) regulate root morphogenesis. Ding L, et al. Plant J, 2008 Jan. PMID 17999646

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity.
      Title: Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity.
    2. XLG3 interaction with PUB4 and PUB2
      Title: EXTRA-LARGE G PROTEINs Interact with E3 Ligases PUB4 and PUB2 and Function in Cytokinin and Developmental Processes.
    3. XLGs can bind Gbetagamma dimers.
      Title: Extra-Large G Proteins Expand the Repertoire of Subunits in Arabidopsis Heterotrimeric G Protein Signaling.
    4. study describes initial functional characterization of XLG1, XLG2 & XZLG3 genes & reveals a role for XLG proteins in the regulation of root growth and seed germination by sugars and phytohormones
      Title: Arabidopsis extra-large G proteins (XLGs) regulate root morphogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    • At1g31930_Arabidopsis_lyrata_ssp._lyrata_CAN1 (e-PCR)
    • At1g31930_Arabidopsis_lyrata_ssp._petraea_GER1 (e-PCR)
    NM_001198196.1
    NM_001332988.1
    NM_001332989.1
    NM_001332990.1
    NM_102929.2
    NM_179406.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gravitropism IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of root morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethylene IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fructose IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to glucose IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to mannitol IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to sucrose IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within thigmotropism IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    extra-large GTP-binding protein 3
    NP_001185125.1
    • extra-large GTP-binding protein 3 (XLG3); FUNCTIONS IN: signal transducer activity, guanyl nucleotide binding; INVOLVED IN: in 11 processes; LOCATED IN: nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Guanine nucleotide binding protein (G-protein), alpha subunit (InterPro:IPR001019), G protein alpha subunit, helical insertion (InterPro:IPR011025); BEST Arabidopsis thaliana protein match is: extra-large G-protein 1 (TAIR:AT2G23460.1).
    NP_001319126.1
    • extra-large GTP-binding protein 3 (XLG3); FUNCTIONS IN: guanyl nucleotide binding, signal transducer activity; INVOLVED IN: in 11 processes; LOCATED IN: nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Guanine nucleotide binding protein (G-protein), alpha subunit (InterPro:IPR001019), G protein alpha subunit, helical insertion (InterPro:IPR011025); BEST Arabidopsis thaliana protein match is: extra-large G-protein 1 (TAIR:AT2G23460.1); Has 3436 Blast hits to 3429 proteins in 399 species: Archae - 0; Bacteria - 2; Metazoa - 2221; Fungi - 595; Plants - 371; Viruses - 0; Other Eukaryotes - 247 (source: NCBI BLink).
    NP_849737.1
    • extra-large GTP-binding protein 3 (XLG3); FUNCTIONS IN: signal transducer activity, guanyl nucleotide binding; INVOLVED IN: in 11 processes; LOCATED IN: nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Guanine nucleotide binding protein (G-protein), alpha subunit (InterPro:IPR001019), G protein alpha subunit, helical insertion (InterPro:IPR011025); BEST Arabidopsis thaliana protein match is: extra-large G-protein 1 (TAIR:AT2G23460.1); Has 3436 Blast hits to 3429 proteins in 399 species: Archae - 0; Bacteria - 2; Metazoa - 2221; Fungi - 595; Plants - 371; Viruses - 0; Other Eukaryotes - 247 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11464934..11469207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179406.2 → NP_849737.1  extra-large GTP-binding protein 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849737.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C516
      UniProtKB/TrEMBL
      A0A178WJF6, A0A5S9WKJ0
      Conserved Domains (2) summary
      cd00066
      Location:431 → 818
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      pfam00503
      Location:429 → 815
      G-alpha; G-protein alpha subunit

    2. NM_001198196.1 → NP_001185125.1  extra-large GTP-binding protein 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185125.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C516
      UniProtKB/TrEMBL
      A0A178WJF6, A0A5S9WKJ0
      Conserved Domains (2) summary
      cd00066
      Location:431 → 818
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      pfam00503
      Location:429 → 815
      G-alpha; G-protein alpha subunit

    3. NM_001332988.1 → NP_001319126.1  extra-large GTP-binding protein 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C516
      UniProtKB/TrEMBL
      A0A178WJF6, A0A5S9WKJ0

    4. NM_102929.2 → NP_174475.1  extra-large GTP-binding protein 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174475.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C516
      UniProtKB/TrEMBL
      A0A178WJF6, A0A5S9WKJ0
      Conserved Domains (2) summary
      cd00066
      Location:431 → 818
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      pfam00503
      Location:429 → 815
      G-alpha; G-protein alpha subunit

    5. NM_001332989.1 → NP_001320661.1  extra-large GTP-binding protein 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C516
      UniProtKB/TrEMBL
      A0A178WJF6, A0A5S9WKJ0

    6. NM_001332990.1 → NP_001320662.1  extra-large GTP-binding protein 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C516
      UniProtKB/TrEMBL
      A0A178WJF6, A0A5S9WKJ0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C516.1

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