GGPS1 geranylgeranyl pyrophosphate synthase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GGPS1
Official Full Name: geranylgeranyl pyrophosphate synthase 1
Primary source: TAIR:AT4G36810
Locus tag: AT4G36810
See related: Araport:AT4G36810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtGGPPS11; AtLSU; geranyl(geranyl)diphosphate synthase 11; geranylgeranyl pyrophosphate synthase 1; GGPPS11; Large subunit of Heterodimeric geranyl(geranyl)diphosphate synthase; LSU
Summary: Encodes a protein with geranylgeranyl pyrophosphate synthase activity involved in isoprenoid biosynthesis. The enzyme appears to be targeted to the chloroplast in epidermal cells and guard cells of leaves, and in etioplasts in roots.
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Genomic context

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See GGPS1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (17343374..17345171)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GGPPS11 is a hub isozyme required for the production of most photosynthesis-related isoprenoids. Both gene co-expression and protein-protein interaction likely contribute to the channeling of geranylgeranyl diphosphate (GGPP) by GGPPS11.
Title: Arabidopsis GERANYLGERANYL DIPHOSPHATE SYNTHASE 11 is a hub isozyme required for the production of most photosynthesis-related isoprenoids.
GGPS1 is a key gene in the chlorophyll biosynthetic pathway.
Title: Mutations in GERANYLGERANYL DIPHOSPHATE SYNTHASE 1 affect chloroplast development in Arabidopsis thaliana (Brassicaceae).

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_119845.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables dimethylallyltranstransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables farnesyltranstransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables geranyltranstransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in farnesyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in geranyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in geranylgeranyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within isoprenoid biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within monoterpene biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in etioplast	IDA Inferred from Direct Assay more info	PubMed
located_in plastid	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: geranylgeranyl pyrophosphate synthase 1

NP_195399.1

geranylgeranyl pyrophosphate synthase 1 (GGPS1); FUNCTIONS IN: farnesyltranstransferase activity; INVOLVED IN: isoprenoid biosynthetic process; LOCATED IN: etioplast, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Polyprenyl synthetase-related (InterPro:IPR017446), Terpenoid synthase (InterPro:IPR008949), Polyprenyl synthetase (InterPro:IPR000092); BEST Arabidopsis thaliana protein match is: Terpenoid synthases superfamily protein (TAIR:AT2G18620.1); Has 16617 Blast hits to 16612 proteins in 2936 species: Archae - 341; Bacteria - 9385; Metazoa - 291; Fungi - 423; Plants - 452; Viruses - 12; Other Eukaryotes - 5713 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

17343374..17345171

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119845.3 → NP_195399.1 geranylgeranyl pyrophosphate synthase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195399.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O23201, P34802

UniProtKB/TrEMBL

A0A178UX98, A0A384KAT6, Q0WUL9, Q8LAW5

Conserved Domains (1) summary

cd00685
Location:103 → 369

Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail