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    Ndufs6 NADH:ubiquinone oxidoreductase core subunit S6 [ Mus musculus (house mouse) ]

    Gene ID: 407785, updated on 11-Jan-2025

    Summary

    Official Symbol
    Ndufs6provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit S6provided by MGI
    Primary source
    MGI:MGI:107932
    See related
    Ensembl:ENSMUSG00000021606 AllianceGenome:MGI:107932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IP13
    Summary
    Acts upstream of or within several processes, including DNA damage response, signal transduction by p53 class mediator; mesenchymal stem cell proliferation; and mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in limb; respiratory system; and skeleton. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in cervical cancer and nuclear type mitochondrial complex I deficiency 9. Orthologous to human NDUFS6 (NADH:ubiquinone oxidoreductase subunit S6). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in heart adult (RPKM 124.2), placenta adult (RPKM 69.8) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Ndufs6 in Genome Data Viewer
    Location:
    13 C1; 13 39.69 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (73467995..73476574, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73319876..73328482, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Iroquois homeobox 4 Neighboring gene VISTA enhancer mm68 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34990 Neighboring gene mitochondrial ribosomal protein L36 Neighboring gene STARR-seq mESC enhancer starr_34991 Neighboring gene ephemeron, early developmental lncRNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC107676

    Gene Ontology Provided by MGI

    Items 1 - 25 of 27
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator PubMed 
    involved_in aerobic respiration PubMed 
    acts_upstream_of_or_within cell growth PubMed 
    acts_upstream_of_or_within cell growth PubMed 
    acts_upstream_of_or_within cellular senescence PubMed 
    acts_upstream_of_or_within cellular senescence PubMed 
    acts_upstream_of_or_within circulatory system development PubMed 
    acts_upstream_of_or_within fatty acid metabolic process PubMed 
    acts_upstream_of_or_within gene expression PubMed 
    acts_upstream_of_or_within kidney development PubMed 
    acts_upstream_of_or_within mesenchymal stem cell differentiation PubMed 
    acts_upstream_of_or_within mesenchymal stem cell differentiation PubMed 
    acts_upstream_of_or_within mesenchymal stem cell proliferation PubMed 
    acts_upstream_of_or_within mesenchymal stem cell proliferation PubMed 
    involved_in mitochondrial electron transport, NADH to ubiquinone  
    involved_in mitochondrial electron transport, NADH to ubiquinone  
    acts_upstream_of_or_within mitochondrial respiratory chain complex I assembly PubMed 
    acts_upstream_of_or_within mitochondrion organization PubMed 
    acts_upstream_of_or_within multicellular organism growth PubMed 
    acts_upstream_of_or_within muscle contraction PubMed 
    involved_in proton motive force-driven mitochondrial ATP synthesis PubMed 
    acts_upstream_of_or_within reactive oxygen species metabolic process PubMed 
    acts_upstream_of_or_within regulation of mitochondrial membrane potential PubMed 
    acts_upstream_of_or_within reproductive system development PubMed 
    acts_upstream_of_or_within respiratory electron transport chain PubMed 
    acts_upstream_of_or_within stem cell division PubMed 
    acts_upstream_of_or_within stem cell division PubMed 
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    is_active_in intracellular anatomical structure PubMed 
    is_active_in mitochondrial inner membrane PubMed 
    located_in mitochondrial inner membrane  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    is_active_in mitochondrion PubMed 
    part_of respiratory chain complex I  
    part_of respiratory chain complex I PubMed 
    part_of respiratory chain complex I  
    part_of respiratory chain complex I  

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
    Names
    CI-13kD-A
    NADH dehydrogenase (ubiquinone) Fe-S protein 6
    NADH dehydrogenase Fe-S protein 6
    NADH-ubiquinone oxidoreductase 13 kDa-A subunit
    complex I-13kD-A
    NP_001410642.1
    NP_001410643.1
    NP_001410644.1
    NP_001410645.1
    NP_001410646.1
    NP_035018.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423713.1NP_001410642.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC154266
    2. NM_001423714.1NP_001410643.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC154266
      UniProtKB/TrEMBL
      A0A1Y7VM38
    3. NM_001423715.1NP_001410644.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC154266
    4. NM_001423716.1NP_001410645.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC154266
    5. NM_001423717.1NP_001410646.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC154266
    6. NM_010888.3NP_035018.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_035018.1

      Status: VALIDATED

      Source sequence(s)
      AC154266
      Consensus CDS
      CCDS26630.1
      UniProtKB/Swiss-Prot
      P52503, Q5M9J7
      UniProtKB/TrEMBL
      A0A1Y7VM38
      Related
      ENSMUSP00000022097.6, ENSMUST00000022097.6
      Conserved Domains (1) summary
      pfam10276
      Location:75111
      zf-CHCC; Zinc-finger domain

    RNA

    1. NR_033306.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154266
      Related
      ENSMUST00000147407.2
    2. NR_187109.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154266
    3. NR_187110.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154266
    4. NR_187112.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154266
    5. NR_187113.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154266
    6. NR_187114.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154266

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      73467995..73476574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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