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    Tnfaip2 tumor necrosis factor, alpha-induced protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 21928, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnfaip2provided by MGI
    Official Full Name
    tumor necrosis factor, alpha-induced protein 2provided by MGI
    Primary source
    MGI:MGI:104960
    See related
    Ensembl:ENSMUSG00000021281 AllianceGenome:MGI:104960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B94; M-sec; Tnfip2; tnfb94; Exoc3l3
    Summary
    Predicted to enable SNARE binding activity. Predicted to be involved in exocyst localization and exocytosis. Predicted to be part of exocyst. Is expressed in several structures, including embryo mesenchyme; future brain; genitourinary system; immune system; and sensory organ. Used to study focal segmental glomerulosclerosis. Orthologous to human TNFAIP2 (TNF alpha induced protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 39.6), liver E14.5 (RPKM 31.1) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnfaip2 in Genome Data Viewer
    Location:
    12 F1; 12 60.99 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111408898..111421452)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111442450..111455018)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene LBH domain containing 2 Neighboring gene exocyst complex component 3-like 4 Neighboring gene predicted gene, 40578 Neighboring gene predicted gene 266 Neighboring gene STARR-positive B cell enhancer ABC_E138 Neighboring gene small nucleolar RNA, H/ACA box 28 Neighboring gene eukaryotic translation initiation factor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tnfaip2 promotes atherogenesis by enhancing oxidative stress induced inflammation. Jin G, et al. Mol Immunol, 2022 Nov. PMID 36084515
    2. Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy. Barutta F, et al. Autophagy, 2023 Feb. PMID 35659195, Free PMC Article
    3. Protective Role of the M-Sec-Tunneling Nanotube System in Podocytes. Barutta F, et al. J Am Soc Nephrol, 2021 May 3. PMID 33722931, Free PMC Article
    4. Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice. Jiajia H, et al. BMC Cardiovasc Disord, 2023 Nov 18. PMID 37980507, Free PMC Article
    5. M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex. Hase K, et al. Nat Cell Biol, 2009 Dec. PMID 19935652

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice.
      Title: Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice.
    2. Tnfaip2 promotes atherogenesis by enhancing oxidative stress induced inflammation.
      Title: Tnfaip2 promotes atherogenesis by enhancing oxidative stress induced inflammation.
    3. Knockdown of TNFaip2 in Raw264.7 cells inhibited formation of tunneling nanotubes.
      Title: M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocyst localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor alpha-induced protein 2
    Names
    TNF alpha-induced protein 2
    primary response gene B94 protein
    tumor necrosis factor induced protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009396.2 → NP_033422.2  tumor necrosis factor alpha-induced protein 2

      See identical proteins and their annotated locations for NP_033422.2

      Status: VALIDATED

      Source sequence(s)
      BP767166, BY202445, L24118
      Consensus CDS
      CCDS26178.2
      UniProtKB/Swiss-Prot
      Q3T9B0, Q3TCH9, Q61333, Q922G1
      UniProtKB/TrEMBL
      D3Z4L9
      Related
      ENSMUSP00000099806.4, ENSMUST00000102745.10
      Conserved Domains (1) summary
      pfam06046
      Location:157 → 688
      Sec6; Exocyst complex component Sec6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111408898..111421452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515793.5 → XP_006515856.1  tumor necrosis factor alpha-induced protein 2 isoform X2

      Conserved Domains (1) summary
      cl19885
      Location:157 → 412
      Sec6; Exocyst complex component Sec6

    2. XM_036157378.1 → XP_036013271.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    RNA

    1. XR_381521.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61333.2 GenPept UniProtKB/Swiss-Prot:Q61333

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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