Ren1 renin 1 structural [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ren1provided by MGI
Official Full Name: renin 1 structuralprovided by MGI
Primary source: MGI:MGI:97898
See related: Ensembl:ENSMUSG00000070645 AllianceGenome:MGI:97898
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ren; Rnr; Rn-1; Ren-1; Ren-A; Ren1c; Ren1d
Summary: Enables aspartic-type endopeptidase activity. Involved in angiotensin maturation; male gonad development; and mesonephros development. Acts upstream of or within with a positive effect on regulation of blood pressure. Acts upstream of or within several processes, including drinking behavior; hormone-mediated signaling pathway; and renin-angiotensin regulation of aldosterone production. Located in extracellular space. Is active in extracellular region. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and trunk. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 87.3) and ovary adult (RPKM 3.3) See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 57.91 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (133278412..133288058)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (133350674..133360320)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system.
Title: Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system.
In Vivo Renin Activity Imaging in the Kidney of Progeroid Ercc1 Mutant Mice.
Title: In Vivo Renin Activity Imaging in the Kidney of Progeroid Ercc1 Mutant Mice.
Advances in use of mouse models to study the renin-angiotensin system.
Title: Advances in use of mouse models to study the renin-angiotensin system.
Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis.
Title: Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis.
Intermittent Hypoxia Upregulates the Renin and Cd38 mRNAs in Renin-Producing Cells via the Downregulation of miR-203.
Title: Intermittent Hypoxia Upregulates the Renin and Cd38 mRNAs in Renin-Producing Cells via the Downregulation of miR-203.
Alteration of Cx37, Cx40, Cx43, Cx45, Panx1, and Renin Expression Patterns in Postnatal Kidneys of Dab1-/- (yotari) Mice.
Title: Alteration of Cx37, Cx40, Cx43, Cx45, Panx1, and Renin Expression Patterns in Postnatal Kidneys of Dab1-/- (yotari) Mice.
Ctcf is required for renin expression and maintenance of the structural integrity of the kidney.
Title: Ctcf is required for renin expression and maintenance of the structural integrity of the kidney.
This study reveals that the human renin protein is able to complement the mouse Ren1d(-/-) non-granulated defect and suggests that granulopoiesis requires a structural motif that is conserved between the mouse Ren1d and human renin proteins.
Title: Phenotypic dissection of the mouse Ren1d knockout by complementation with human renin.
These observations demonstrate that activation of the renin-angiotensin system (RAS) promotes colitis in a blood pressure independent manner. Angiotensin II appears to drive colonic mucosal inflammation by promoting intestinal epithelial cell apoptosis and mucosal TH17 responses in colitis development.
Title: Activation of the Renin-Angiotensin System Promotes Colitis Development.
PGE2 serves as a central regulator of the Ren-1c gene in the principal cells of the kidney collecting ducts via the PKC/cAMP/CREB pathway.
Title: PGE(2) upregulates renin through E-prostanoid receptor 1 via PKC/cAMP/CREB pathway in M-1 cells.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (11) 1 citation

General gene information

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Markers

D16Mit18 (e-PCR), detects polymorphism
- UniSTS:142085

D1Mit1012 (e-PCR), detects polymorphism
- UniSTS:142086

Ren1 (e-PCR), detects polymorphism
- UniSTS:464689

D16Mit18 (e-PCR), detects polymorphism
- UniSTS:127811

D19352 (e-PCR)
- UniSTS:158852

D1Mit31 (e-PCR), detects polymorphism
- UniSTS:128665

D1Mit31.1 (e-PCR), detects polymorphism
- UniSTS:128666

Ren1 (e-PCR), detects polymorphism
- UniSTS:545979

X16642 (e-PCR)
- UniSTS:163263

Ren1 (e-PCR), detects polymorphism
- UniSTS:144345

Ren2 (e-PCR), detects polymorphism
- UniSTS:507386

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta metabolic process	IEA Inferred from Electronic Annotation more info
involved_in angiotensin maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiotensin maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within angiotensin maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiotensin maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within drinking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within establishment of blood-nerve barrier	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hormone-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in juxtaglomerular apparatus development	IEA Inferred from Electronic Annotation more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mesonephros development	IEP Inferred from Expression Pattern more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood volume by renin-angiotensin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within renin-angiotensin regulation of aldosterone production	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in response to cGMP	IEA Inferred from Electronic Annotation more info
involved_in response to cGMP	ISO Inferred from Sequence Orthology more info
involved_in response to immobilization stress	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: renin-1

Names: angiotensinogenase; aspartyl-protease; kidney renin; renin b

NP_112469.1

EC 3.4.23.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031192.3 → NP_112469.1 renin-1 precursor

See identical proteins and their annotated locations for NP_112469.1

Status: VALIDATED

Source sequence(s)

AC068906, AK085309

Consensus CDS

CCDS15295.1

UniProtKB/Swiss-Prot

P00796, P06281, P70229, P97911, P97955, Q543E5, Q62153, Q62154, Q62155

Related

ENSMUSP00000092135.3, ENSMUST00000094556.3

Conserved Domains (3) summary

cd05487
Location:76 → 401

renin_like; Renin stimulates production of angiotensin and thus affects blood pressure

pfam00026
Location:83 → 401

Asp; Eukaryotic aspartyl protease

pfam07966
Location:29 → 54

A1_Propeptide; A1 Propeptide