Nudt3 nudix hydrolase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudt3provided by MGI
Official Full Name: nudix hydrolase 3provided by MGI
Primary source: MGI:MGI:1928484
See related: Ensembl:ENSMUSG00000024213 AllianceGenome:MGI:1928484
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dipp; Dipp1; 1110011B09Rik
Summary: Enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity and 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity. Involved in RNA decapping. Is active in glutamatergic synapse. Orthologous to human NUDT3 (nudix hydrolase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 71.3), adrenal adult (RPKM 66.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 14.59 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (27798356..27842426, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (27579382..27623452, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

studies revealed abundant Nudt3 mRNA and protein expression in the mouse brain, including reward- and feeding-related regions of hypothalamus and amygdala, and Nudt3 mRNA expression was up-regulated in hypothalamus and brainstem of food-deprived mice.
Title: The Obesity-Linked Gene Nudt3 Drosophila Homolog Aps Is Associated With Insulin Signaling.
Ectopic expression of murine DIPP1 (muDIPP1)inhibits signal transduction through the ERK1/2 pathway.
Title: Ectopic expression of murine diphosphoinositol polyphosphate phosphohydrolase 1 attenuates signaling through the ERK1/2 pathway.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	ISO Inferred from Sequence Orthology more info
enables bis(5'-adenosyl)-hexaphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-adenosyl)-pentaphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diphosphoinositol-polyphosphate diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diphosphoinositol-polyphosphate diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables diphosphoinositol-polyphosphate diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables endopolyphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopolyphosphatase activity	IEA Inferred from Electronic Annotation more info
enables endopolyphosphatase activity	ISO Inferred from Sequence Orthology more info
enables inositol diphosphate pentakisphosphate diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables inositol diphosphate tetrakisphosphate diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables inositol diphosphate tetrakisphosphate diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA decapping	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA decapping	ISO Inferred from Sequence Orthology more info
involved_in RNA decapping	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diadenosine hexaphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diadenosine hexaphosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in diadenosine hexaphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in diadenosine pentaphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diphosphoinositol polyphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in diphosphoinositol polyphosphate catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in diphosphoinositol polyphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: diphosphoinositol polyphosphate phosphohydrolase 1

Names: DIPP-1; ap6A hydrolase; diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1; diadenosine hexaphosphate hydrolase; endopolyphosphatase; m7GpppN-mRNA hydrolase; m7GpppX diphosphatase; nudix (nucleoside diphosphate linked moiety X)-type motif 3; nudix (nucleotide diphosphate linked moiety X)-type motif 3

NP_001277975.1

EC 3.6.1.10

EC 3.6.1.52

EC 3.6.1.59

EC 3.6.1.61

EC 3.6.1.62

NP_062811.1

EC 3.6.1.10

EC 3.6.1.52

EC 3.6.1.59

EC 3.6.1.61

EC 3.6.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291046.1 → NP_001277975.1 diphosphoinositol polyphosphate phosphohydrolase 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 5' terminal exon compared to variant 1. The resulting protein (isoform 1) is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AC127341, AC131800, BU919402

Consensus CDS

CCDS70776.1

UniProtKB/TrEMBL

A0A338P6T6, B2KF67

Related

ENSMUSP00000110536.2, ENSMUST00000114886.8

Conserved Domains (1) summary

cd04666
Location:4 → 105

Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
NM_019837.2 → NP_062811.1 diphosphoinositol polyphosphate phosphohydrolase 1 isoform 1

See identical proteins and their annotated locations for NP_062811.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

AC127341, AC131800

Consensus CDS

CCDS28566.1

UniProtKB/Swiss-Prot

B2KF68, Q6PG02, Q8BV71, Q9JI46

UniProtKB/TrEMBL

I1E4X7

Related

ENSMUSP00000025050.6, ENSMUST00000025050.13

Conserved Domains (1) summary

cd04666
Location:19 → 134

Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...