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    Zfp410 zinc finger protein 410 [ Mus musculus (house mouse) ]

    Gene ID: 52708, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp410provided by MGI
    Official Full Name
    zinc finger protein 410provided by MGI
    Primary source
    MGI:MGI:1289280
    See related
    Ensembl:ENSMUSG00000042472 AllianceGenome:MGI:1289280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apa1; Znf410; D12Ertd748e
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of gene expression and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromosome and nucleus. Is expressed in several structures, including 1st branchial arch; early conceptus; genitourinary system; maxillary process; and telencephalon. Orthologous to human ZNF410 (zinc finger protein 410). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.5), CNS E14 (RPKM 5.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp410 in Genome Data Viewer
    Location:
    12 D1; 12 39.15 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84363615..84391213)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84316510..84344439)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10765 Neighboring gene prostaglandin reductase 2 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene family with sequence similarity 161, member B Neighboring gene STARR-positive B cell enhancer ABC_E1445 Neighboring gene coenzyme Q6 monooxygenase Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:85729760-85729947 Neighboring gene basal body orientation factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1. Benanti JA, et al. Mol Cell Biol, 2002 Nov. PMID 12370286, Free PMC Article
    2. ZNF410 represses fetal globin by singular control of CHD4. Vinjamur DS, et al. Nat Genet, 2021 May. PMID 33859416, Free PMC Article
    3. Diversification of stem cell molecular repertoire by alternative splicing. Pritsker M, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16183747, Free PMC Article
    4. Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Campbell GR, et al. Mol Cell Neurosci, 2011 Feb. PMID 21194568, Free PMC Article
    5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38535

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 410
    Names
    another partner for ARF 1
    zinc finger protein APA-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252582.2 → NP_001239511.1  zinc finger protein 410 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI449605, AK033090, AK051939, BB657543, CK791111, DT918547
      Consensus CDS
      CCDS88369.1
      UniProtKB/Swiss-Prot
      Q8BKX7
      Related
      ENSMUSP00000152441.2, ENSMUST00000222258.2
      Conserved Domains (3) summary
      sd00017
      Location:251 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:266 → 292
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:251 → 334
      zf-C2H2_8; C2H2-type zinc ribbon

    2. NM_001252583.1 → NP_001239512.1  zinc finger protein 410 isoform 3

      See identical proteins and their annotated locations for NP_001239512.1

      Status: VALIDATED

      Source sequence(s)
      BB466060, BC052080, CK791111
      Consensus CDS
      CCDS88368.1
      UniProtKB/Swiss-Prot
      Q8BKX7
      Related
      ENSMUSP00000152098.2, ENSMUST00000220931.2
      Conserved Domains (3) summary
      sd00017
      Location:251 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:266 → 292
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:251 → 335
      zf-C2H2_8; C2H2-type zinc ribbon

    3. NM_001364223.1 → NP_001351152.1  zinc finger protein 410 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC159649
      Conserved Domains (2) summary
      sd00017
      Location:200 → 220
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:198 → 220
      zf-C2H2; Zinc finger, C2H2 type

    4. NM_001423121.1 → NP_001410050.1  zinc finger protein 410 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC159649
      UniProtKB/Swiss-Prot
      Q8BKX7, Q8BWB3, Q8BZZ7, Q8R5L2, Q8VDL2

    5. NM_001423122.1 → NP_001410051.1  zinc finger protein 410 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC159649
      UniProtKB/Swiss-Prot
      Q8BKX7, Q8BWB3, Q8BZZ7, Q8R5L2, Q8VDL2

    6. NM_001423123.1 → NP_001410052.1  zinc finger protein 410 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC159649

    7. NM_001423124.1 → NP_001410053.1  zinc finger protein 410 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC159649

    8. NM_144833.4 → NP_659082.1  zinc finger protein 410 isoform 1

      See identical proteins and their annotated locations for NP_659082.1

      Status: VALIDATED

      Source sequence(s)
      AC159649, AK051939, AK132345, CK791111
      Consensus CDS
      CCDS26042.1
      UniProtKB/Swiss-Prot
      Q8BKX7, Q8BWB3, Q8BZZ7, Q8R5L2, Q8VDL2
      Related
      ENSMUSP00000045550.11, ENSMUST00000045931.12
      Conserved Domains (3) summary
      COG5189
      Location:189 → 300
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:281 → 303
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:325 → 350
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_045546.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159649, AK051939, BC056957, CK791111

    2. NR_045615.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159649, AK051939

    3. NR_157102.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159649

    4. NR_157103.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159649

    5. NR_186734.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159649
      Related
      ENSMUST00000222606.2

    6. NR_186735.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159649

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84363615..84391213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BKX7.2 GenPept UniProtKB/Swiss-Prot:Q8BKX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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