avr-14 Ig-like domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: avr-14
Official Full Name: Ig-like domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein
Primary source: WormBase:WBGene00000232
Locus tag: CELE_B0207.12
See related: AllianceGenome:WB:WBGene00000232
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables extracellularly glutamate-gated chloride channel activity. Involved in several processes, including locomotion involved in locomotory behavior; monoatomic ion transport; and regulation of nematode pharyngeal pumping. Located in membrane. Is expressed in head; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in hyperekplexia 1 and syndromic X-linked intellectual disability Pilorge type. Orthologous to human GLRA1 (glycine receptor alpha 1); GLRA2 (glycine receptor alpha 2); and GLRA3 (glycine receptor alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See avr-14 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 19

Sequence:: Chromosome: I; NC_003279.8 (5967247..5973326, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

B0207.12 (e-PCR)
- UniSTS:313363

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly glutamate-gated chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in locomotion involved in locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of nematode pharyngeal pumping	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ig-like domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein

NP_001020963.1

Confirmed by transcript evidence

NP_001370303.1

Confirmed by transcript evidence

NP_001379546.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5967247..5973326 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025792.5 → NP_001020963.1 Ig-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020963.1

Status: REVIEWED

UniProtKB/TrEMBL

Q17369, Q95Q97

Conserved Domains (3) summary

TIGR00860
Location:20 → 424

LIC; Cation transporter family protein

pfam02931
Location:27 → 253

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:260 → 355

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001392384.1 → NP_001379546.1 Ig-like domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q17367, Q95Q96

Conserved Domains (1) summary

TIGR00860
Location:20 → 414

LIC; Cation transporter family protein
NM_001383181.1 → NP_001370303.1 Neurotransmitter-gated ion-channel ligand-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8IFY7

Conserved Domains (1) summary

TIGR00860
Location:20 → 238

LIC; Cation transporter family protein