cdh-4 Cadherin-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cdh-4
Official Full Name: Cadherin-4
Primary source: WormBase:WBGene00000396
Locus tag: CELE_F25F2.2
See related: AllianceGenome:WB:WBGene00000396
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in membrane. Predicted to be active in cell-cell junction. Is expressed in several structures, including QL; nervous system; non-striated muscle; rectum; and reproductive system. Human ortholog(s) of this gene implicated in carcinoma (multiple); colorectal cancer; and spinocerebellar ataxia 45. Orthologous to human FAT1 (FAT atypical cadherin 1); FAT2 (FAT atypical cadherin 2); and FAT3 (FAT atypical cadherin 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cdh-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 21

Sequence:: Chromosome: III; NC_003281.10 (4520357..4536994)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

loss of the cell adhesion molecule (CAM) CDH-4/Fat-like cadherin causes dendrites to be ordered randomly, despite remaining bundled. Loss of the CAMs PTP-3/LAR or SAX-7/L1CAM causes dendrites to adopt an altered order, which becomes increasingly random as animals grow.
Title: Ordered arrangement of dendrites within a C. elegans sensory nerve bundle.
The fat-like cadherin CDH-4 acts cell-non-autonomously in anterior-posterior neuroblast migration.
Title: The fat-like cadherin CDH-4 acts cell-non-autonomously in anterior-posterior neuroblast migration.
CDH-4 functions to ensure that proper cell contacts are made and maintained during development.
Title: The Fat-like cadherin CDH-4 controls axon fasciculation, cell migration and hypodermis and pharynx development in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F25F2.2 (e-PCR)
- UniSTS:309935

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cadherin-4

NP_001317871.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4520357..4536994

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001330837.3 → NP_001317871.1 LOW QUALITY PROTEIN: Cadherin-4 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1C3NSI5, G5EE05, Q19319, Q19785, Q21606

Conserved Domains (7) summary

cd11304
Location:724 → 822

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:416 → 490

CA; Cadherin repeats

smart00282
Location:3781 → 3907

LamG; Laminin G domain

cd00053
Location:3710 → 3749

EGF; Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional ...

cd00054
Location:3968 → 4004

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:3933 → 3963

EGF; EGF-like domain

cl29226
Location:2941 → 3009

Cadherin; Cadherin domain