eat-16 RGS domain-containing protein;Regulator of G-protein signaling 7 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: eat-16
Official Full Name: RGS domain-containing protein;Regulator of G-protein signaling 7
Primary source: WormBase:WBGene00001145
Locus tag: CELE_C16C2.2
See related: AllianceGenome:WB:WBGene00001145
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTPase activator activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of nematode pharyngeal pumping; and response to serotonin. Located in cytoplasm; neuron projection; and plasma membrane. Is expressed in neurons; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in bradyopsia 1. Orthologous to human RGS9 (regulator of G protein signaling 9). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See eat-16 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (9722716..9726284)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EAT-16 and RSBP-1 act together to selectively inhibit D1 dopamine receptor signaling in cholinergic motor neurons to modulate locomotion behavior.
Title: D1 dopamine receptor signaling is modulated by the R7 RGS protein EAT-16 and the R7 binding protein RSBP-1 in Caenoerhabditis elegans motor neurons.
Membrane targeting by RSBP-1 is essential for EAT-16 activity.
Title: RSBP-1 is a membrane-targeting subunit required by the Galpha(q)-specific but not the Galpha(o)-specific R7 regulator of G protein signaling in Caenorhabditis elegans.
the N-terminal region of EAT-16 directs inhibition of G(alpha) signaling by forming a complex with the GGL/RGS region and affecting its stability, membrane localization, and G(alpha) target specificity
Title: An N-terminal region of Caenorhabditis elegans RGS proteins EGL-10 and EAT-16 directs inhibition of G(alpha)o versus G(alpha)q signaling.
RGS-7 appears to promote G protein function asymmetrically in the cell, perhaps acting as a G protein effector.
Title: RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C16C2.2 (e-PCR)
- UniSTS:321228

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled dopamine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phospholipase C-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to food	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to serotonin	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RGS domain-containing protein;Regulator of G-protein signaling 7

NP_740904.1

Confirmed by transcript evidence

NP_740905.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9722716..9726284

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170912.6 → NP_740905.1 RGS domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_740905.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T3F0

Conserved Domains (3) summary

smart00224
Location:204 → 266

GGL; G protein gamma subunit-like motifs

cd04450
Location:18 → 94

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

cl02565
Location:280 → 405

RGS; Regulator of G protein signaling (RGS) domain superfamily
NM_170911.6 → NP_740904.1 Regulator of G-protein signaling 7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_740904.1

Status: REVIEWED

UniProtKB/TrEMBL

O17589

Conserved Domains (3) summary

smart00224
Location:204 → 266

GGL; G protein gamma subunit-like motifs

cd08705
Location:280 → 405

RGS_R7-like; Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins

cd04450
Location:18 → 94

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...