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    ifd-1 Intermediate filament protein ifd-1 [ Caenorhabditis elegans ]

    Gene ID: 187585, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ifd-1
    Official Full Name
    Intermediate filament protein ifd-1
    Primary source
    WormBase:WBGene00002057
    Locus tag
    CELE_R04E5.10
    See related
    AllianceGenome:WB:WBGene00002057
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be located in cytoplasm and intermediate filament. Predicted to be active in nuclear envelope and nuclear lamina. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ifd-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (8820703..8824448, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene tRNA-Gly Neighboring gene RING-type domain-containing protein Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers. Arnold ML, et al. Nat Commun, 2023 Jul 24. PMID 37488107, Free PMC Article
    2. Promiscuous Dimerization Between the Caenorhabditis elegans IF Proteins and a Hypothesis to Explain How Multiple IFs Persist Over Evolutionary Time. Karabinos A, et al. J Mol Evol, 2019 Sep. PMID 31407015
    3. Intermediate filament (IF) proteins IFA-1 and IFB-1 represent a basic heteropolymeric IF cytoskeleton of nematodes: A molecular phylogeny of nematode IFs. Karabinos A. Gene, 2019 Apr 15. PMID 30641223
    4. Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions. Geisler F, et al. Elife, 2023 Jun 7. PMID 37283438, Free PMC Article
    5. Analysis of the novel excretory cell expressed ECP-1 protein and its proposed ECP-1/IFC-2 fusion protein EXC-2 in the nematode Caenorhabditis elegans. Karabinos A, et al. Gene Expr Patterns, 2019 Dec. PMID 31207388

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear lamina IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Intermediate filament protein ifd-1
    NP_001024830.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8820703..8824448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029659.5 → NP_001024830.1  Intermediate filament protein ifd-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024830.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86DC6, Q9GYL1
      Conserved Domains (3) summary
      pfam00038
      Location:53 → 404
      Filament; Intermediate filament protein
      pfam00932
      Location:465 → 569
      LTD; Lamin Tail Domain
      pfam07462
      Location:167 → 348
      MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86DC6.2

    Gene LinkOut

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