bir-2 Baculoviral IAP repeat-containing protein bir-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: bir-2
Official Full Name: Baculoviral IAP repeat-containing protein bir-2
Primary source: WormBase:WBGene00000250
Locus tag: CELE_C50B8.2
See related: AllianceGenome:WB:WBGene00000250
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within with a positive effect on germ cell proliferation. Predicted to be part of chromosome passenger complex. Predicted to be active in cytoplasm; kinetochore; and spindle midzone. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; prostate cancer; and pulmonary hypertension. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2); BIRC3 (baculoviral IAP repeat containing 3); and BIRC5 (baculoviral IAP repeat containing 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See bir-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (13568850..13570030)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C50B8.3 (e-PCR)
- UniSTS:313914

C50B8.2 (e-PCR)
- UniSTS:309357

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect germ cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Baculoviral IAP repeat-containing protein bir-2

NP_506362.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13568850..13570030

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073961.6 → NP_506362.1 Baculoviral IAP repeat-containing protein bir-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506362.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECJ5

Conserved Domains (1) summary

smart00238
Location:23 → 99

BIR; Baculoviral inhibition of apoptosis protein repeat