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    dnj-12 DNaJ domain (prokaryotic heat shock protein) [ Caenorhabditis elegans ]

    Gene ID: 173341, updated on 9-Dec-2024

    Summary

    Official Symbol
    dnj-12
    Official Full Name
    DNaJ domain (prokaryotic heat shock protein)
    Primary source
    WormBase:WBGene00001030
    Locus tag
    CELE_F39B2.10
    See related
    AllianceGenome:WB:WBGene00001030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ATPase activator activity. Predicted to be involved in protein refolding. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; pharynx; and reproductive system. Orthologous to human DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1) and DNAJA4 (DnaJ heat shock protein family (Hsp40) member A4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See dnj-12 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (14757063..14758787)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box/LRR-repeat protein Neighboring gene Metaxin-1 homolog Neighboring gene Transmembrane protein 107 Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein eS26

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATPase activator activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNaJ domain (prokaryotic heat shock protein)
    NP_493570.1
    • Product from WormBase gene class dnj;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14757063..14758787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061169.8NP_493570.1  DNaJ domain (prokaryotic heat shock protein) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45502
      Conserved Domains (4) summary
      cd10719
      Location:136201
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:200334
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:2401
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:765
      DnaJ; DnaJ domain