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    acs-21 fatty Acid CoA Synthetase family [ Caenorhabditis elegans ]

    Gene ID: 178751, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acs-21
    Official Full Name
    fatty Acid CoA Synthetase family
    Primary source
    WormBase:WBGene00016849
    Locus tag
    CELE_C50H11.1
    See related
    AllianceGenome:WB:WBGene00016849
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable medium-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Human ortholog(s) of this gene implicated in combined malonic and methylmalonic acidemia. Orthologous to human ACSF3 (acyl-CoA synthetase family member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acs-21 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (3089068..3091352)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Serpentine Receptor, class T Neighboring gene CYtochrome P450 family Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables medium-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fatty Acid CoA Synthetase family
    NP_503845.1
    • Product from WormBase gene class acs;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3089068..3091352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071444.4 → NP_503845.1  fatty Acid CoA Synthetase family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503845.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16481
      Conserved Domains (2) summary
      PRK07514
      Location:40 → 517
      PRK07514; malonyl-CoA synthase; Validated
      cd05941
      Location:38 → 505
      MCS; Malonyl-CoA synthetase (MCS)
    Nucleotide Protein
    Heading Accession and Version

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