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    gpap-1 inositol-phosphate phosphatase [ Caenorhabditis elegans ]

    Gene ID: 173241, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpap-1
    Official Full Name
    inositol-phosphate phosphatase
    Primary source
    WormBase:WBGene00012390
    Locus tag
    CELE_Y6B3B.5
    See related
    AllianceGenome:WB:WBGene00012390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3'-nucleotidase activity. Predicted to be located in membrane. Predicted to be active in endomembrane system. Human ortholog(s) of this gene implicated in chondrodysplasia with joint dislocations gPAPP type. Orthologous to human BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpap-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (13751234..13756354, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative ceramide synthase lagr-1 Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein;TRAM domain-containing protein Neighboring gene Activin_recp domain-containing protein Neighboring gene S phase cyclin A-associated protein in the endoplasmic reticulum N-terminal domain-containing protein Neighboring gene Copper transport protein 86

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of Lithium-Sensitive Phosphatase BPNT-1 Causes Selective Neuronal Dysfunction in C. elegans. Meisel JD, et al. Curr Biol, 2016 Jul 25. PMID 27397889, Free PMC Article
    2. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inositol-phosphate phosphatase
    NP_001021802.1
    • Confirmed by transcript evidence
    NP_001359521.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13751234..13756354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373655.4 → NP_001359521.1  inositol-phosphate phosphatase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWE8
      Conserved Domains (1) summary
      cd01640
      Location:43 → 332
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    2. NM_001026631.4 → NP_001021802.1  inositol-phosphate phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021802.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5ZEQ3
      Conserved Domains (1) summary
      cd01640
      Location:52 → 341
      IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
    Nucleotide Protein
    Heading Accession and Version

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