rme-2 EGF-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rme-2
Official Full Name: EGF-like domain-containing protein
Primary source: WormBase:WBGene00004374
Locus tag: CELE_T11F8.3
See related: AllianceGenome:WB:WBGene00004374
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables low-density lipoprotein particle receptor activity. Involved in embryo development; oocyte development; and ovulation. Located in endosome membrane and plasma membrane. Is expressed in germ cell; germ line; and gonad. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rme-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (5470026..5473174)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T11F8.3 (e-PCR)
- UniSTS:310803

Y52D5A.c (e-PCR)
- UniSTS:323056

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovulation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: EGF-like domain-containing protein

NP_001368360.1

Confirmed by transcript evidence

NP_500815.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

5470026..5473174

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068414.7 → NP_500815.2 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500815.2

Status: REVIEWED

UniProtKB/TrEMBL

O44191, Q9N4S4, Q9U4E4

Conserved Domains (5) summary

smart00135
Location:552 → 594

LY; Low-density lipoprotein-receptor YWTD domain

cd00112
Location:75 → 109

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:527 → 568

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:309 → 337

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:337 → 375

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001380231.1 → NP_001368360.1 EGF-like domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q9U4E4, V6CIR8

Conserved Domains (5) summary

smart00135
Location:473 → 515

LY; Low-density lipoprotein-receptor YWTD domain

cd00112
Location:3 → 30

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:448 → 489

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:230 → 258

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:258 → 296

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...