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    pgp-10 P-GlycoProtein related [ Caenorhabditis elegans ]

    Gene ID: 180981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pgp-10
    Official Full Name
    P-GlycoProtein related
    Primary source
    WormBase:WBGene00004004
    Locus tag
    CELE_C54D1.1
    See related
    AllianceGenome:WB:WBGene00004004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in hypodermis and intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pgp-10 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    29
    Sequence:
    Chromosome: X; NC_003284.9 (7159036..7166021)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Antimicrobial peptide Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Beta-catenin/armadillo-related protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Resistance to the macrocyclic lactone moxidectin is mediated in part by membrane transporter P-glycoproteins: Implications for control of drug resistant parasitic nematodes. Bygarski EE, et al. Int J Parasitol Drugs Drug Resist, 2014 Dec. PMID 25516824, Free PMC Article
    2. The ABC transporter gene family of Caenorhabditis elegans has implications for the evolutionary dynamics of multidrug resistance in eukaryotes. Sheps JA, et al. Genome Biol, 2004. PMID 15003118, Free PMC Article
    3. Comparative genomics and adaptive selection of the ATP-binding-cassette gene family in caenorhabditis species. Zhao Z, et al. Genetics, 2007 Mar. PMID 17194779, Free PMC Article
    4. Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle. Schroeder LK, et al. Mol Biol Cell, 2007 Mar. PMID 17202409, Free PMC Article
    5. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    P-GlycoProtein related
    NP_509205.2
    • Product from WormBase gene class pgp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7159036..7166021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076804.5 → NP_509205.2  P-GlycoProtein related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509205.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18824
      Conserved Domains (4) summary
      cd03249
      Location:450 → 687
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      COG1132
      Location:73 → 687
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      cl00549
      Location:823 → 1099
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:1141 → 1381
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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