idhb-1 putative isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: idhb-1
Official Full Name: putative isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Primary source: WormBase:WBGene00007993
Locus tag: CELE_C37E2.1
See related: AllianceGenome:WB:WBGene00007993
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable isocitrate dehydrogenase (NAD+) activity and metal ion binding activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in several structures, including body wall musculature; head; pharynx; reproductive system; and tail neurons. Human ortholog(s) of this gene implicated in retinitis pigmentosa 46. Orthologous to human IDH3B (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See idhb-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (14170864..14173389, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C37E2.1 (e-PCR)
- UniSTS:309275

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables isocitrate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in isocitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

NP_510362.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

14170864..14173389 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077961.9 → NP_510362.1 putative isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510362.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93353

Conserved Domains (1) summary

TIGR00175
Location:40 → 377

mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type