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    unc-27 Troponin I 2 [ Caenorhabditis elegans ]

    Gene ID: 181124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-27
    Official Full Name
    Troponin I 2
    Primary source
    WormBase:WBGene00006764
    Locus tag
    CELE_ZK721.2
    See related
    AllianceGenome:WB:WBGene00006764
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables troponin C binding activity. Involved in locomotion and sarcomere organization. Located in sarcomere. Is expressed in body wall musculature; non-striated muscle; and rectal muscle. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; distal arthrogryposis type 2B1; and intrinsic cardiomyopathy (multiple). Orthologous to human TNNI1 (troponin I1, slow skeletal type); TNNI2 (troponin I2, fast skeletal type); and TNNI3 (troponin I3, cardiac type). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-27 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (8789456..8790621)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA Neighboring gene Cholesterol uptake protein 1 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of Caenorhabditis elegans muscle structure and function caused by mutation of troponin I. Burkeen AK, et al. Biophys J, 2004 Feb. PMID 14747334, Free PMC Article
    2. Molecular evolution of troponin I and a role of its N-terminal extension in nematode locomotion. Barnes DE, et al. Cytoskeleton (Hoboken), 2016 Mar. PMID 26849746, Free PMC Article
    3. Troponin I controls ovulatory contraction of non-striated actomyosin networks in the C. elegans somatic gonad. Obinata T, et al. J Cell Sci, 2010 May 1. PMID 20388732, Free PMC Article
    4. Effect of dys-1 mutation on gene expression profile in space-flown Caenorhabditis elegans. Xu D, et al. Muscle Nerve, 2018 Jan 18. PMID 29346705
    5. A decline in transcript abundance for Heterodera glycines homologs of Caenorhabditis elegans uncoordinated genes accompanies its sedentary parasitic phase. Klink VP, et al. BMC Dev Biol, 2007 Apr 19. PMID 17445261, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables troponin C binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in sarcomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of troponin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Troponin I 2
    NP_509488.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8789456..8790621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077087.9 → NP_509488.2  Troponin I 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509488.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5FBV6, Q9GYF1
      Conserved Domains (1) summary
      pfam00992
      Location:46 → 178
      Troponin; Troponin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GYF1.2

    Gene LinkOut

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