unc-15 Paramyosin [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-15
Official Full Name: Paramyosin
Primary source: WormBase:WBGene00006754
Locus tag: CELE_F07A5.7
See related: AllianceGenome:WB:WBGene00006754
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables SH3 domain binding activity; cytoskeletal protein binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of ovulation; positive regulation of sarcomere organization; and skeletal muscle myosin thick filament assembly. Located in A band and myosin filament. Is expressed in alimentary muscle; body wall musculature; gonad; and vulval muscle. Orthologous to human MYH16 (myosin heavy chain 16). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-15 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 12

Sequence:: Chromosome: I; NC_003279.8 (7376604..7383197, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

model in which UNC-98 and -96 may act as chaperones to promote the incorporation of paramyosin into thick filaments
Title: UNC-98 and UNC-96 interact with paramyosin to promote its incorporation into thick filaments of Caenorhabditis elegans.
UNC-96 interacts with UNC-98, a previously described component of M-lines, and paramyosin.
Title: Caenorhabditis elegans UNC-96 is a new component of M-lines that interacts with UNC-98 and paramyosin and is required in adult muscle for assembly and/or maintenance of thick filaments.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F07A5.7 (e-PCR)
- UniSTS:309569

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables Rho-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables SH3 domain binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytoskeletal protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in anatomical structure formation involved in morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cellular component assembly	IEA Inferred from Electronic Annotation more info
involved_in cortical actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle myosin thick filament assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in skeletal muscle myosin thick filament assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in supramolecular fiber organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in A band	IDA Inferred from Direct Assay more info	PubMed
located_in A band	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in myosin filament	IDA Inferred from Direct Assay more info	PubMed
located_in myosin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Paramyosin

NP_001367193.1

Confirmed by transcript evidence

NP_001379131.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7376604..7383197 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392551.1 → NP_001379131.1 Paramyosin [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

B3WFV3, P10567, Q93214, Q93439

Conserved Domains (1) summary

pfam01576
Location:32 → 839

Myosin_tail_1; Myosin tail
NM_001380695.1 → NP_001367193.1 Paramyosin [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

pfam01576
Location:21 → 520

Myosin_tail_1; Myosin tail