pgp-14 P-glycoprotein 14 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: pgp-14
Official Full Name: P-glycoprotein 14
Primary source: WormBase:WBGene00004008
Locus tag: CELE_F22E10.3
See related: AllianceGenome:WB:WBGene00004008
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in response to nematicide. Predicted to be active in membrane. Is expressed in pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See pgp-14 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (12744723..12749580, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PGP-14 establishes a polar lipid permeability barrier within the C. elegans pharyngeal cuticle.
Title: PGP-14 establishes a polar lipid permeability barrier within the C. elegans pharyngeal cuticle.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F22E10.3 (e-PCR)
- UniSTS:307525

STS6-191 (e-PCR)
- UniSTS:242575

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in response to chemical	IEA Inferred from Electronic Annotation more info
involved_in response to nematicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: P-glycoprotein 14

NP_510128.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

12744723..12749580 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077727.10 → NP_510128.1 P-glycoprotein 14 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510128.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EG61

Conserved Domains (4) summary

cd03249
Location:429 → 666

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:104 → 1321

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:109 → 377

ABC_membrane; ABC transporter transmembrane region

cl00549
Location:769 → 1039

ABC_membrane; ABC transporter transmembrane region