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    top-1 DNA topoisomerase 1 [ Caenorhabditis elegans ]

    Gene ID: 266847, updated on 4-Jan-2025

    Summary

    Official Symbol
    top-1
    Official Full Name
    DNA topoisomerase 1
    Primary source
    WormBase:WBGene00006595
    Locus tag
    CELE_M01E5.5
    See related
    AllianceGenome:WB:WBGene00006595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication; DNA topological change; and chromosome segregation. Located in nucleolus and spindle pole centrosome. Is expressed in several structures, including excretory cell; germ line; gonad; neurons; and oocyte. Orthologous to human TOP1 (DNA topoisomerase I) and TOP1MT (DNA topoisomerase I mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See top-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (13292506..13297558)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RNase NYN domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ncRNA

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in DNA replication  
    involved_in DNA topological change  
    involved_in DNA topological change  
    involved_in chromosome segregation  
    Component Evidence Code Pubs
    located_in chromosome  
    is_active_in nucleolus  
    located_in nucleolus PubMed 
    located_in nucleolus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in spindle pole centrosome PubMed 

    General protein information

    Preferred Names
    DNA topoisomerase 1
    NP_001379240.1
    • Confirmed by transcript evidence
    NP_493337.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13292506..13297558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392963.1 → NP_001379240.1  DNA topoisomerase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      smart00435
      Location:330 → 703
      TOPEUc; DNA Topoisomerase I (eukaryota)
      cd03488
      Location:186 → 400
      Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    2. NM_060936.8 → NP_493337.1  DNA topoisomerase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17965, O17966, Q27529
      Conserved Domains (4) summary
      smart00435
      Location:402 → 775
      TOPEUc; DNA Topoisomerase I (eukaryota)
      cd03488
      Location:258 → 472
      Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
      pfam01028
      Location:474 → 684
      Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
      pfam14370
      Location:733 → 795
      Topo_C_assoc; C-terminal topoisomerase domain
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