cts-1 putative citrate synthase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cts-1
Official Full Name: putative citrate synthase, mitochondrial
Primary source: WormBase:WBGene00000833
Locus tag: CELE_T20G5.2
See related: AllianceGenome:WB:WBGene00000833
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable citrate (Si)-synthase activity. Predicted to be involved in carbohydrate metabolic process and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cts-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (10214771..10216635, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T20G5.2 (e-PCR)
- UniSTS:308065

T20G5.11 (e-PCR)
- UniSTS:310915

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity, acyl groups converted into alkyl on transfer	IEA Inferred from Electronic Annotation more info
enables citrate (Si)-synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables citrate (Si)-synthase activity	IEA Inferred from Electronic Annotation more info
enables citrate (Si)-synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables citrate synthase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbohydrate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in citrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative citrate synthase, mitochondrial

NP_499264.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10214771..10216635 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066863.9 → NP_499264.1 putative citrate synthase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499264.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34575

Conserved Domains (2) summary

cd06105
Location:35 → 462

ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...

PLN02456
Location:33 → 461

PLN02456; citrate synthase