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    mgl-3 G-protein coupled receptors family 3 profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177327, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mgl-3
    Official Full Name
    G-protein coupled receptors family 3 profile domain-containing protein
    Primary source
    WormBase:WBGene00021152
    Locus tag
    CELE_Y4C6A.2
    See related
    AllianceGenome:WB:WBGene00021152
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable adenylate cyclase inhibiting G protein-coupled glutamate receptor activity. Involved in positive regulation of lipid storage. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in NSM; head neurons; and nerve ring. Human ortholog(s) of this gene implicated in alcohol dependence; attention deficit hyperactivity disorder; autistic disorder; congenital stationary night blindness 1B; and schizophrenia. Orthologous to several human genes including GRM8 (glutamate metabotropic receptor 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mgl-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    18
    Sequence:
    Chromosome: IV; NC_003282.8 (5439005..5450802)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RING-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabotropic Glutamate Receptors: MODULATORS OF CONTEXT-DEPENDENT FEEDING BEHAVIOUR IN C. ELEGANS. Dillon J, et al. J Biol Chem, 2015 Jun 12. PMID 25869139, Free PMC Article
    2. Molecular characterization of the metabotropic glutamate receptor family in Caenorhabditis elegans. Dillon J, et al. Biochem Soc Trans, 2006 Nov. PMID 17052233
    3. Absence of metabotropic glutamate receptor homolog(s) accelerates acetylcholine neurotransmission in Caenorhabditis elegans. Sadananda G, et al. Neurosci Lett, 2021 Feb 16. PMID 33493646
    4. Obesogenic effect of erythromycin on Caenorhabditis elegans through over-eating and lipid metabolism disturbances. Luo Z, et al. Environ Pollut, 2022 Feb 1. PMID 34863891
    5. Identification of a spontaneously arising variant affecting thermotaxis behavior in a recombinant inbred Caenorhabditis elegans line. Yeon J, et al. G3 (Bethesda), 2023 Sep 30. PMID 37572357, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of lipid storage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 3 profile domain-containing protein
    NP_001076735.3
    • Partially confirmed by transcript evidence
    NP_001299986.1
    • Partially confirmed by transcript evidence
    NP_001299987.1
    • Partially confirmed by transcript evidence
    NP_001299988.1
    • Partially confirmed by transcript evidence
    NP_001299989.1
    • Partially confirmed by transcript evidence
    NP_741400.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5439005..5450802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083266.5 → NP_001076735.3  G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076735.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1IMB8
      Conserved Domains (3) summary
      cd15934
      Location:577 → 825
      7tmC_mGluRs_group2_3; metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:507 → 556
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:41 → 493
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    2. NM_171341.5 → NP_741400.2  G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741400.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXU2
      Conserved Domains (3) summary
      cd15934
      Location:577 → 825
      7tmC_mGluRs_group2_3; metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:507 → 556
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:41 → 493
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    3. NM_001313057.3 → NP_001299986.1  G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AV56
      Conserved Domains (3) summary
      cd15934
      Location:167 → 415
      7tmC_mGluRs_group2_3; metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:97 → 146
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:2 → 79
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    4. NM_001313058.3 → NP_001299987.1  G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXG3
      Conserved Domains (3) summary
      cd15934
      Location:167 → 415
      7tmC_mGluRs_group2_3; metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:97 → 146
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:2 → 79
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    5. NM_001313059.3 → NP_001299988.1  G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AS42
      Conserved Domains (2) summary
      cd14964
      Location:5 → 26
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1 → 217
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. NM_001313060.3 → NP_001299989.1  G-protein coupled receptors family 3 profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUI1
      Conserved Domains (2) summary
      cd14964
      Location:5 → 26
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1 → 217
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. NR_132461.1 RNA Sequence

      Status: REVIEWED

    2. NR_132462.1 RNA Sequence

      Status: REVIEWED

    3. NR_132463.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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