nep-12 Neprilysin [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nep-12
Official Full Name: Neprilysin
Primary source: WormBase:WBGene00017842
Locus tag: CELE_F26G1.6
See related: AllianceGenome:WB:WBGene00017842
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human KEL (Kell metallo-endopeptidase (Kell blood group)). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nep-12 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 15

Sequence:: Chromosome: II; NC_003280.10 (4775284..4784536, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F26G1.6 (e-PCR)
- UniSTS:309977

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Neprilysin

NP_001364536.1

Confirmed by transcript evidence

NP_001364537.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

4775284..4784536 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001377790.1 → NP_001364536.1 Neprilysin [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9MND8

Conserved Domains (1) summary

cd08662
Location:111 → 770

M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
NM_001377789.2 → NP_001364537.1 Neprilysin [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9MNU9

Conserved Domains (1) summary

cd08662
Location:171 → 830

M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I