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    mlt-7 Peroxidase mlt-7 light chain [ Caenorhabditis elegans ]

    Gene ID: 173775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mlt-7
    Official Full Name
    Peroxidase mlt-7 light chain
    Primary source
    WormBase:WBGene00022743
    Locus tag
    CELE_ZK430.8
    See related
    AllianceGenome:WB:WBGene00022743
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables peroxidase activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle; nematode larval development; and post-embryonic body morphogenesis. Predicted to be active in extracellular space. Is expressed in hypodermal cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mlt-7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (4393007..4404850)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene NOT2/NOT3/NOT5 C-terminal domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Forkhead transcription factor fkh-6 Neighboring gene separase Neighboring gene Superoxide dismutase [Cu-Zn]

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dityrosine Crosslinking of Collagen and Amyloid-β Peptides Is Formed by Vitamin B(12) Deficiency-Generated Oxidative Stress in Caenorhabditis elegans. Koseki K, et al. Int J Mol Sci, 2021 Nov 30. PMID 34884761, Free PMC Article
    2. Deficit in the epidermal barrier induces toxicity and translocation of PEG modified graphene oxide in nematodes. Zhao L, et al. Toxicol Res (Camb), 2018 Nov 1. PMID 30510679, Free PMC Article
    3. Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans. Moribe H, et al. PLoS Genet, 2012 Sep. PMID 23028364, Free PMC Article
    4. Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans. Thein MC, et al. J Biol Chem, 2009 Jun 26. PMID 19406744, Free PMC Article
    5. Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity. Shioda T, et al. Proc Natl Acad Sci U S A, 2023 Sep 26. PMID 37722055, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lactoperoxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic body morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in post-embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peroxidase mlt-7 light chain
    NP_494777.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4393007..4404850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062376.7 → NP_494777.1  Peroxidase mlt-7 light chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494777.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23490
      Conserved Domains (3) summary
      cd09823
      Location:328 → 688
      peroxinectin_like; peroxinectin_like animal heme peroxidases
      pfam01549
      Location:41 → 76
      ShK; ShK domain-like
      pfam03098
      Location:191 → 691
      An_peroxidase; Animal haem peroxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23490.1

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