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    unc-24 Band 7 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-24
    Official Full Name
    Band 7 domain-containing protein
    Primary source
    WormBase:WBGene00006761
    Locus tag
    CELE_F57H12.2
    See related
    AllianceGenome:WB:WBGene00006761
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human STOML1 (stomatin like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-24 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (7979870..7982011)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene DUF148 domain-containing protein Neighboring gene Onchocerca Related Antigen family Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ADP-ribosylation factor Neighboring gene Alpha-tubulin N-acetyltransferase 1;N-acetyltransferase domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A stomatin and a degenerin interact in lipid rafts of the nervous system of Caenorhabditis elegans. Sedensky MM, et al. Am J Physiol Cell Physiol, 2004 Aug. PMID 15102610
    2. The alpha and beta subunits of nematode actin capping protein function in yeast. Waddle JA, et al. Mol Biol Cell, 1993 Sep. PMID 8257793, Free PMC Article
    3. Understanding anesthesia: making genetic sense of the absence of senses. Humphrey JA, et al. Hum Mol Genet, 2002 May 15. PMID 12015284
    4. Dominant unc-37 mutations suppress the movement defect of a homeodomain mutation in unc-4, a neural specificity gene in Caenorhabditis elegans. Miller DM 3rd, et al. Genetics, 1993 Nov. PMID 7904971, Free PMC Article
    5. MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain. Zhang S, et al. Curr Biol, 2004 Nov 9. PMID 15530389

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. unc-1, unc-24, and ssu-1 are neuronal stomatin-like proteins sharing regulatory roles with a sulfotransferase enzyme
      Title: Sulfated signal from ASJ sensory neurons modulates stomatin-dependent coordination in Caenorhabditis elegans.
    2. Mutations in the unc-24 gene alter the distribution of UNC-1 in lipid rafts
      Title: A stomatin and a degenerin interact in lipid rafts of the nervous system of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Band 7 domain-containing protein
    NP_001355386.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7979870..7982011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001368443.4 → NP_001355386.1  Band 7 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED76, Q7KPQ9
      Conserved Domains (2) summary
      pfam02036
      Location:338 → 437
      SCP2; SCP-2 sterol transfer family
      cl19107
      Location:146 → 263
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    Nucleotide Protein
    Heading Accession and Version

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