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    pha-1 F-box domain-containing protein;FTH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176543, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pha-1
    Official Full Name
    F-box domain-containing protein;FTH domain-containing protein
    Primary source
    WormBase:WBGene00004010
    Locus tag
    CELE_Y48A6C.5
    See related
    AllianceGenome:WB:WBGene00004010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable alpha-(1->3)-fucosyltransferase activity. Involved in embryonic digestive tract morphogenesis and nematode larval development. Located in cytoplasm. Is expressed in body wall muscle cell and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pha-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (11131775..11136688)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Pre-rRNA-processing protein Ipi1 N-terminal domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF38 domain-containing protein Neighboring gene F-box C protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CLC chloride channels in Caenorhabditis elegans. Schriever AM, et al. J Biol Chem, 1999 Nov 26. PMID 10567397
    2. Genetics: Master Regulator or Master of Disguise? Ailion M, et al. Curr Biol, 2017 Sep 11. PMID 28898647
    3. Functional GATA- and initiator-like-elements exhibit a similar arrangement in the promoters of Caenorhabditis elegans polyamine synthesis enzymes. Lüersen K, et al. Biol Chem, 2004 Aug. PMID 15449707
    4. Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1. Zaborin A, et al. Proc Natl Acad Sci U S A, 2009 Apr 14. PMID 19369215, Free PMC Article
    5. Substantial rDNA copy number reductions alter timing of development and produce variable tissue-specific phenotypes in C. elegans. Morton EA, et al. Genetics, 2023 May 4. PMID 36919976, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Authors discovered a selfish element causing embryonic lethality in crosses between wild strains; the element is made up of sup-35, a maternal-effect toxin that kills developing embryos, and pha-1, its zygotically expressed antidote. pha-1 has long been considered essential for pharynx development on the basis of its mutant phenotype, but this phenotype arises from a loss of suppression of sup-35 toxicity.
      Title: A maternal-effect selfish genetic element in Caenorhabditis elegans.
    2. PHA-1 regulates the expression of several components of two apical junction complexes including AJM-1-DLG-1/discs large complex and the classical cadherin-catenin complex.
      Title: Analysis of PHA-1 reveals a limited role in pharyngeal development and novel functions in other tissues.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic digestive tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryonic digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reproductive process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box domain-containing protein;FTH domain-containing protein
    NP_001022890.1
    • Confirmed by transcript evidence
    NP_001022891.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11131775..11136688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027720.3 → NP_001022891.1  FTH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022891.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YXC4
      Conserved Domains (1) summary
      pfam06542
      Location:51 → 438
      PHA-1; Regulator protein PHA-1

    2. NM_001027719.5 → NP_001022890.1  F-box domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022890.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGL5
      Conserved Domains (1) summary
      pfam06542
      Location:89 → 476
      PHA-1; Regulator protein PHA-1
    Nucleotide Protein
    Heading Accession and Version

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