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    ceh-18 Homeobox protein ceh-18;POU domain protein [ Caenorhabditis elegans ]

    Gene ID: 180671, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ceh-18
    Official Full Name
    Homeobox protein ceh-18;POU domain protein
    Primary source
    WormBase:WBGene00000441
    Locus tag
    CELE_ZC64.3
    See related
    AllianceGenome:WB:WBGene00000441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of oocyte maturation; and oocyte maturation. Located in nucleus. Is expressed in body wall musculature; gonad; neurons; non-striated muscle; and somatic nervous system. Orthologous to several human genes including POU2F2 (POU class 2 homeobox 2) and POU2F3 (POU class 2 homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ceh-18 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (3843367..3857797, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Transthyretin-like family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation. Greenstein D, et al. Genes Dev, 1994 Aug 15. PMID 7958868
    2. Characterization of the Caenorhabditis elegans Islet LIM-homeodomain ortholog, lim-7. Voutev R, et al. FEBS Lett, 2009 Jan 22. PMID 19116151, Free PMC Article
    3. Communication between oocytes and somatic cells regulates volatile pheromone production in Caenorhabditis elegans. Leighton DH, et al. Proc Natl Acad Sci U S A, 2014 Dec 16. PMID 25453110, Free PMC Article
    4. Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6. Bürglin TR, et al. Development, 2001 Mar. PMID 11171402
    5. Eph and NMDA receptors control Ca2+/calmodulin-dependent protein kinase II activation during C. elegans oocyte meiotic maturation. Corrigan C, et al. Development, 2005 Dec. PMID 16267094

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ovulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox protein ceh-18;POU domain protein
    NP_001391077.1
    • Confirmed by transcript evidence
    NP_741758.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3843367..3857797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171659.7 → NP_741758.1  Homeobox protein ceh-18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741758.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41934
      Conserved Domains (2) summary
      smart00352
      Location:290 → 364
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:424 → 478
      Homeobox; Homeobox domain

    2. NM_001404200.1 → NP_001391077.1  POU domain protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7R9SVK5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41934.1

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