U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ptc-3 Protein patched homolog 3 [ Caenorhabditis elegans ]

    Gene ID: 173631, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ptc-3
    Official Full Name
    Protein patched homolog 3
    Primary source
    WormBase:WBGene00004210
    Locus tag
    CELE_Y110A2AL.8
    See related
    AllianceGenome:WB:WBGene00004210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in molting cycle. Located in apical plasma membrane and cytoplasmic vesicle. Is expressed in several structures, including CEP; egg-laying apparatus; excretory duct; male-specific anatomical entity; and preanal ganglion. Human ortholog(s) of this gene implicated in carcinoma (multiple); holoprosencephaly (multiple); medulloblastoma; nevoid basal cell carcinoma syndrome (multiple); and stomach cancer. Orthologous to human PTCH1 (patched 1) and PTCH2 (patched 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ptc-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (2845412..2852593, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene FAD-oxidase_C domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. C. elegans patched-3 is an essential gene implicated in osmoregulation and requiring an intact permease transporter domain. Soloviev A, et al. Dev Biol, 2011 Mar 15. PMID 21215260, Free PMC Article
    2. Patched regulates lipid homeostasis by controlling cellular cholesterol levels. Cadena Del Castillo CE, et al. Nat Commun, 2021 Aug 12. PMID 34385431, Free PMC Article
    3. Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans. Wang C, et al. Neurobiol Dis, 2018 Jan. PMID 28982592
    4. Transcriptomic Analysis Reveals JAK2/MPL-Independent Effects of Calreticulin Mutations in a C. elegans Model. Guijarro-Hernández A, et al. Cells, 2023 Jan 2. PMID 36611979, Free PMC Article
    5. Periodic subcellular structures undergo long-range synchronized reorganization during C. elegans epidermal development. Wang C, et al. J Cell Sci, 2020 Nov 3. PMID 33033182, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Consistent with this pattern of expression, ptc-3(RNAi) reveals an additional postembryonic requirement for ptc-3 activity
      Title: C. elegans patched-3 is an essential gene implicated in osmoregulation and requiring an intact permease transporter domain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hedgehog family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hedgehog receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables smoothened binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Protein patched homolog 3
    NP_001122650.1
    • Confirmed by transcript evidence
    NP_494383.2
    • Confirmed by transcript evidence
    NP_494384.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      2845412..2852593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061983.9 → NP_494384.2  Protein patched homolog 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494384.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2L0G5
      Conserved Domains (2) summary
      TIGR00918
      Location:46 → 1298
      2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family
      cl21543
      Location:647 → 796
      MMPL; MMPL family

    2. NM_061982.8 → NP_494383.2  Protein patched homolog 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494383.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2L0G5
      Conserved Domains (2) summary
      TIGR00918
      Location:46 → 1301
      2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family
      cl21543
      Location:647 → 796
      MMPL; MMPL family

    3. NM_001129178.3 → NP_001122650.1  Protein patched homolog 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122650.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2L0G4, H2L0G5, Q6AW16
      Conserved Domains (2) summary
      TIGR00918
      Location:55 → 1307
      2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family
      cl21543
      Location:656 → 805
      MMPL; MMPL family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H2L0G5.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous