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    lpr-1 LiPocalin-Related protein;Lipocln_cytosolic_FA-bd_dom domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171648, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lpr-1
    Official Full Name
    LiPocalin-Related protein;Lipocln_cytosolic_FA-bd_dom domain-containing protein
    Primary source
    WormBase:WBGene00002393
    Locus tag
    CELE_Y65B4BR.2
    See related
    AllianceGenome:WB:WBGene00002393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in nematode larval development and tube development. Predicted to be located in extracellular region. Is expressed in several structures, including P1; P10; P11; excretory system; and hypodermal cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lpr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (557375..561671)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase wwp-1 Neighboring gene SSD domain-containing protein Neighboring gene ncRNA Neighboring gene Lipase_GDSL domain-containing protein Neighboring gene Homeobox protein ceh-9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipocalins Are Required for Apical Extracellular Matrix Organization and Remodeling in Caenorhabditis elegans. Forman-Rubinsky R, et al. Genetics, 2017 Oct. PMID 28842397, Free PMC Article
    2. The Lipocalin LPR-1 Cooperates with LIN-3/EGF Signaling To Maintain Narrow Tube Integrity in Caenorhabditis elegans. Pu P, et al. Genetics, 2017 Mar. PMID 28040739, Free PMC Article
    3. Lipocalin signaling controls unicellular tube development in the Caenorhabditis elegans excretory system. Stone CE, et al. Dev Biol, 2009 May 15. PMID 19269285, Free PMC Article
    4. Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Johnsen RC, et al. Mol Gen Genet, 2000 Mar. PMID 10778742
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lpr-1 is required to build a properly organized apical extracellular matrix in epithelial cells.
      Title: Lipocalins Are Required for Apical Extracellular Matrix Organization and Remodeling in Caenorhabditis elegans.
    2. LPR-1 is required to maintain apical membrane integrity and a continuous lumen in the excretory duct through a LIN-3/EGF-independent mechanism.
      Title: The Lipocalin LPR-1 Cooperates with LIN-3/EGF Signaling To Maintain Narrow Tube Integrity in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in lipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tube development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LiPocalin-Related protein;Lipocln_cytosolic_FA-bd_dom domain-containing protein
    NP_001293266.1
    • Confirmed by transcript evidence
    NP_001293267.1
    • Confirmed by transcript evidence
    NP_001293268.1
    • Confirmed by transcript evidence
    NP_001293269.1
    • Confirmed by transcript evidence
    NP_001293270.1
    • Confirmed by transcript evidence
    NP_490752.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      557375..561671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058351.5 → NP_490752.2  Lipocln_cytosolic_FA-bd_dom domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490752.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEP5

    2. NM_001306339.3 → NP_001293268.1  LiPocalin-Related protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293268.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CKQ7

    3. NM_001306341.2 → NP_001293270.1  Lipocln_cytosolic_FA-bd_dom domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293270.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6DX33

    4. NM_001306340.3 → NP_001293269.1  Lipocln_cytosolic_FA-bd_dom domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293269.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6DX32

    5. NM_001306338.4 → NP_001293267.1  Lipocln_cytosolic_FA-bd_dom domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293267.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CJJ4

    6. NM_001306337.3 → NP_001293266.1  Lipocln_cytosolic_FA-bd_dom domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293266.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLX5
      Conserved Domains (1) summary
      cl10502
      Location:53 → 187
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
    Nucleotide Protein
    Heading Accession and Version

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