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    sas-7 Spindle assembly abnormal protein 7 [ Caenorhabditis elegans ]

    Gene ID: 176445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sas-7
    Official Full Name
    Spindle assembly abnormal protein 7
    Primary source
    WormBase:WBGene00011562
    Locus tag
    CELE_T07C4.10
    See related
    AllianceGenome:WB:WBGene00011562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in centriole and cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sas-7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (10321019..10325675)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 Neighboring gene Short coiled-coil protein;Short coiled-coil protein homolog Neighboring gene Annexin Neighboring gene COMM domain-containing protein Neighboring gene JmjC domain-containing protein Neighboring gene ncRNA Neighboring gene Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. How centrioles acquire the ability to reproduce. Ohta M, et al. Elife, 2017 Mar 8. PMID 28271993, Free PMC Article
    2. Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation. Sugioka K, et al. Elife, 2017 Jan 16. PMID 28092264, Free PMC Article
    3. Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos. Gönczy P, et al. Genetics, 2023 May 4. PMID 36988082, Free PMC Article
    4. Extensive programmed centriole elimination unveiled in C. elegans embryos. Kalbfuss N, et al. Sci Adv, 2023 Jun 2. PMID 37256957, Free PMC Article
    5. PCMD-1 bridges the centrioles and the pericentriolar material scaffold in C. elegans. Stenzel L, et al. Development, 2021 Oct 15. PMID 34545391, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spindle assembly abnormal protein 7
    NP_001022754.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10321019..10325675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027583.5 → NP_001022754.1  Spindle assembly abnormal protein 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022754.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBL8
      Conserved Domains (2) summary
      COG1196
      Location:247 → 973
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl21455
      Location:260 → 513
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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