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    atp-4 ATP synthase-coupling factor 6, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 179025, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atp-4
    Official Full Name
    ATP synthase-coupling factor 6, mitochondrial
    Primary source
    WormBase:WBGene00020275
    Locus tag
    CELE_T05H4.12
    See related
    AllianceGenome:WB:WBGene00020275
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable proton transmembrane transporter activity. Predicted to be involved in proton motive force-driven ATP synthesis and proton transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be part of proton-transporting ATP synthase complex. Orthologous to human ATP5PF (ATP synthase peripheral stalk subunit F6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See atp-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (6426246..6427112, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Nucleolar pre-ribosomal-associated protein 1 C-terminal domain-containing protein Neighboring gene tRNA Neighboring gene DUF4706 domain-containing protein Neighboring gene Aldehyde dehydrogenase Neighboring gene Gastrulation defective protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bacterial peptidoglycan muropeptides benefit mitochondrial homeostasis and animal physiology by acting as ATP synthase agonists. Tian D, et al. Dev Cell, 2022 Feb 7. PMID 35045336, Free PMC Article
    2. The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging. Angeli S, et al. Elife, 2021 Sep 1. PMID 34467850, Free PMC Article
    3. RNAi screening for modulators of an osmo-sensitive gene response to extracellular matrix damage reveals negative feedback and interactions with translation inhibition. Chandler LM, et al. PLoS One, 2023. PMID 37155688, Free PMC Article
    4. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. Hansen M, et al. PLoS Genet, 2005 Jul. PMID 16103914, Free PMC Article
    5. The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling. Rüegger S, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25753661, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase-coupling factor 6, mitochondrial
    NP_001379991.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6426246..6427112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392530.1 → NP_001379991.1  ATP synthase-coupling factor 6, mitochondrial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16517
      Conserved Domains (1) summary
      pfam05511
      Location:3 → 62
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
    Nucleotide Protein
    Heading Accession and Version

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