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    msra-1 peptide-methionine (S)-S-oxide reductase [ Caenorhabditis elegans ]

    Gene ID: 185709, updated on 9-Dec-2024

    Summary

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    Official Symbol
    msra-1
    Official Full Name
    peptide-methionine (S)-S-oxide reductase
    Primary source
    WormBase:WBGene00018393
    Locus tag
    CELE_F43E2.5
    See related
    AllianceGenome:WB:WBGene00018393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity and peptide-methionine (S)-S-oxide reductase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be active in cytoplasm. Is expressed in hypodermis; intestine; and neurons. Orthologous to human MSRA (methionine sulfoxide reductase A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See msra-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003280.10 (7363220..7364040, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Endoplasmic reticulum chaperone BiP homolog;Heat shock 70 kDa protein D Neighboring gene ABC-type antigen peptide transporter Neighboring gene Protein inscuteable homologue C-terminal domain-containing protein Neighboring gene Ovule protein Neighboring gene Peptidylprolyl isomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of antioxidant enzyme methionine sulfoxide-S-reductase from Caenorhabditis elegans. Lee BC, et al. Arch Biochem Biophys, 2005 Feb 15. PMID 15639227
    2. Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis. Minniti AN, et al. Aging Cell, 2019 Feb. PMID 30456853, Free PMC Article
    3. The protein oxidation repair enzyme methionine sulfoxide reductase a modulates Aβ aggregation and toxicity in vivo. Minniti AN, et al. Antioxid Redox Signal, 2015 Jan 1. PMID 24988428, Free PMC Article
    4. Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans. Minniti AN, et al. Aging Cell, 2009 Dec. PMID 19747232
    5. Circadian stress tolerance in adult Caenorhabditis elegans. Simonetta SH, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2008 Sep. PMID 18648821

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of antioxidant enzyme methionine sulfoxide-S-reductase from Caenorhabditis elegans [MsrA]
      Title: Cloning and characterization of antioxidant enzyme methionine sulfoxide-S-reductase from Caenorhabditis elegans.
    2. found that the msra-1 gene is expressed in most tissues, particularly in the intestine and the nervous system.
      Title: Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-methionine-(S)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-methionine (S)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (S)-S-oxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-methionine (S)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptide-methionine (S)-S-oxide reductase
    NP_495540.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7363220..7364040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063139.10 → NP_495540.1  peptide-methionine (S)-S-oxide reductase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495540.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02089
      Conserved Domains (1) summary
      pfam01625
      Location:6 → 134
      PMSR; Peptide methionine sulfoxide reductase
    Nucleotide Protein
    Heading Accession and Version

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