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    • Showing Current items.

    acd-1 DEgenerin Like [ Caenorhabditis elegans ]

    Gene ID: 182852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acd-1
    Official Full Name
    DEgenerin Like
    Primary source
    WormBase:WBGene00016064
    Locus tag
    CELE_C24G7.2
    See related
    AllianceGenome:WB:WBGene00016064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ligand-gated sodium channel activity. Involved in response to acidic pH and sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in AMshL and AMshR. Orthologous to human ASIC4 (acid sensing ion channel subunit family member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acd-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    14
    Sequence:
    Chromosome: I; NC_003279.8 (4103698..4108167)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Muscle M-line assembly protein unc-89 Neighboring gene ncRNA Neighboring gene DEgenerin Like Neighboring gene DEgenerin Linked to Mechanosensation Neighboring gene Cyclin N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans. Wang Y, et al. EMBO J, 2008 Sep 17. PMID 18701922, Free PMC Article
    2. Knockout of glial channel ACD-1 exacerbates sensory deficits in a C. elegans mutant by regulating calcium levels of sensory neurons. Wang Y, et al. J Neurophysiol, 2012 Jan. PMID 21994266, Free PMC Article
    3. The Na(+)-K(+)-ATPase is needed in glia of touch receptors for responses to touch in C. elegans. Johnson CK, et al. J Neurophysiol, 2020 May 1. PMID 32292107, Free PMC Article
    4. The glia of Caenorhabditis elegans. Oikonomou G, et al. Glia, 2011 Sep. PMID 21732423, Free PMC Article
    5. Physiological insight into the conserved properties of Caenorhabditis elegans acid-sensing degenerin/epithelial sodium channels. Kaulich E, et al. J Physiol, 2023 May. PMID 36200489, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the glial DEG/ENaC channel ACD-1 functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans
      Title: A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to acidic pH IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DEgenerin Like
    NP_491295.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4103698..4108167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058894.4 → NP_491295.2  DEgenerin Like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491295.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91102
      Conserved Domains (2) summary
      TIGR00867
      Location:83 → 536
      deg-1; degenerin
      pfam00858
      Location:83 → 536
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version

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