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    ndua-13 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [ Caenorhabditis elegans ]

    Gene ID: 172969, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ndua-13
    Official Full Name
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
    Primary source
    WormBase:WBGene00016393
    Locus tag
    CELE_C34B2.8
    See related
    AllianceGenome:WB:WBGene00016393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 28 and oncocytic carcinoma of the thyroid. Orthologous to human NDUFA13 (NADH:ubiquinone oxidoreductase subunit A13). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ndua-13 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (10685825..10687058, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Signal peptidase complex subunit 1 Neighboring gene Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Neighboring gene KNL (kinetochore null) Binding Protein Neighboring gene AGC-kinase C-terminal domain-containing protein;Structural protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans as a model organism for human mitochondrial associated disorders. Maglioni S, et al. Mitochondrion, 2016 Sep. PMID 26906059
    2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
    NP_492799.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10685825..10687058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060398.5 → NP_492799.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492799.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44955
      Conserved Domains (1) summary
      pfam06212
      Location:6 → 135
      GRIM-19; GRIM-19 protein
    Nucleotide Protein
    Heading Accession and Version

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