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    nyn-2 Zc3h12a-like Ribonuclease NYN domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173226, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nyn-2
    Official Full Name
    Zc3h12a-like Ribonuclease NYN domain-containing protein
    Primary source
    WormBase:WBGene00013596
    Locus tag
    CELE_Y87G2A.7
    See related
    AllianceGenome:WB:WBGene00013596
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in siRNA processing. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nyn-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (13572379..13575805)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Carbohydrate sulfotransferase Neighboring gene Ground-like domain-containing protein Neighboring gene peptidylprolyl isomerase Neighboring gene Glucose-6-phosphate isomerase Neighboring gene Ubiquitin-conjugating enzyme E2 S

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of the mutator complex triggers a low penetrance larval arrest phenotype. Rogers AK, et al. MicroPubl Biol, 2020. PMID 32542232, Free PMC Article
    2. A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi. Tsai HY, et al. Cell, 2015 Jan 29. PMID 25635455, Free PMC Article
    3. A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans. Manage KI, et al. Elife, 2020 Apr 27. PMID 32338603, Free PMC Article
    4. Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci. Uebel CJ, et al. PLoS Genet, 2018 Jul. PMID 30036386, Free PMC Article
    5. Diversification of small RNA pathways underlies germline RNA interference incompetence in wild Caenorhabditis elegans strains. Chou HT, et al. Genetics, 2024 Jan 3. PMID 37865119, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in siRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Zc3h12a-like Ribonuclease NYN domain-containing protein
    NP_001370075.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13572379..13575805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383746.2 → NP_001370075.1  Zc3h12a-like Ribonuclease NYN domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NA28
      Conserved Domains (1) summary
      pfam14626
      Location:261 → 384
      RNase_Zc3h12a_2; Zc3h12a-like Ribonuclease NYN domain
    Nucleotide Protein
    Heading Accession and Version

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