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    glct-6 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase [ Caenorhabditis elegans ]

    Gene ID: 4363062, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glct-6
    Official Full Name
    Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
    Primary source
    WormBase:WBGene00019546
    Locus tag
    CELE_W07G9.2
    See related
    AllianceGenome:WB:WBGene00019546
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Predicted to be involved in carbohydrate metabolic process and chondroitin sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus and schizophrenia. Orthologous to human B3GAT1 (beta-1,3-glucuronyltransferase 1) and B3GAT2 (beta-1,3-glucuronyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glct-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (3784210..3794049)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Bestrophin homolog Neighboring gene Ephrin RBD domain-containing protein Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein Neighboring gene Osmotic avoidance abnormal protein 3 Neighboring gene UDP-N-acetylglucosamine transferase subunit ALG14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
    2. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
    NP_001299964.1
    • Confirmed by transcript evidence
    NP_001299965.1
    • Confirmed by transcript evidence
    NP_001367955.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3784210..3794049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313035.3 → NP_001299964.1  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUF6
      Conserved Domains (1) summary
      pfam03360
      Location:125 → 330
      Glyco_transf_43; Glycosyltransferase family 43

    2. NM_001313036.3 → NP_001299965.1  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARJ9
      Conserved Domains (1) summary
      pfam03360
      Location:101 → 306
      Glyco_transf_43; Glycosyltransferase family 43

    3. NM_001380161.2 → NP_001367955.1  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4SN66
      Conserved Domains (1) summary
      pfam03360
      Location:70 → 276
      Glyco_transf_43; Glycosyltransferase family 43
    Nucleotide Protein
    Heading Accession and Version

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