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    abhd-5.2 Abhydrolase domain-containing protein abhd-5.2 [ Caenorhabditis elegans ]

    Gene ID: 178877, updated on 9-Dec-2024

    Summary

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    Official Symbol
    abhd-5.2
    Official Full Name
    Abhydrolase domain-containing protein abhd-5.2
    Primary source
    WormBase:WBGene00016507
    Locus tag
    CELE_C37H5.3
    See related
    AllianceGenome:WB:WBGene00016507
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carboxylic ester hydrolase activity and lysophosphatidic acid acyltransferase activity. Predicted to be involved in lipid homeostasis and phosphatidic acid biosynthetic process. Predicted to be active in lipid droplet and mitochondrion. Is expressed in hypodermis and intestine. Used to study Chanarin-Dorfman syndrome. Human ortholog(s) of this gene implicated in Chanarin-Dorfman syndrome; autosomal recessive congenital ichthyosis 1; and colon adenocarcinoma. Orthologous to human ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B) and ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See abhd-5.2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (4844685..4847025)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Coexpressed With Polycystins Neighboring gene Abhydrolase domain-containing protein abhd-5.1 Neighboring gene Annexin Neighboring gene Acetyltransferase;Acyl-coenzyme A thioesterase 8;RRM_2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Correction: The Causative Gene in Chanarian Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans. Xie M, et al. PLoS Genet, 2016 Dec. PMID 28002418, Free PMC Article
    2. The Causative Gene in Chanarian Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans. Xie M, et al. PLoS Genet, 2015 Jun. PMID 26083785, Free PMC Article
    3. Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration. Yang L, et al. EMBO Rep, 2020 Nov 5. PMID 33034119, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Abhydrolase domain-containing protein abhd-5.2
    NP_504297.1
    • Partially confirmed by transcript evidence
    NP_872178.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4844685..4847025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071896.7 → NP_504297.1  Abhydrolase domain-containing protein abhd-5.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504297.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2KZ86, Q8I7H5
      Conserved Domains (1) summary
      cl26327
      Location:68 → 413
      Abhydrolase_1; alpha/beta hydrolase fold

    2. NM_182378.4 → NP_872178.1  Abhydrolase domain-containing protein abhd-5.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872178.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2KZ86
      Conserved Domains (2) summary
      pfam00561
      Location:76 → 325
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam12695
      Location:77 → 179
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H2KZ86.1

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